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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Oxycodone Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Medicine, Education, Health & Fitness

4.9773 Ratings

🗓️ 9 December 2021

⏱️ 13 minutes

🧾️ Download transcript

Summary

On this episode, I discuss oxycodone pharmacology, adverse effect, pharmacokinetics, and drug interactions.

Oxycodone is broken down by CYP3A4 and CYP2D6. I discuss this further on the podcast and how interactions may alter concentrations.

When a patient stops taking oxycodone after being on it for some time, you must recognize common symptoms of withdrawal.

Oxycodone comes as in an extended-release and immediate-release oral formulation.

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Transcript

Click on a timestamp to play from that location

0:00.0

Hey, all, welcome back to the real-life pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

0:06.1

I thank you so much for listening today. First, I want to apologize a little bit for my voice.

0:11.7

It's a little bit hoarse. And in all honesty, that's why I missed an episode last week. So that was my first miss in probably two and a half for three years. So again,

0:23.0

I apologize for the voice being a little scratchy, but I definitely didn't want to skip two weeks

0:27.9

and make you guys think I disappeared here. So anyway, always go check out real life pharmacology.com.

0:36.3

Go get that free 31 page PDF for the top 200 drugs.

0:40.3

Great resource, whether you're a student or practicing clinician.

0:44.3

And of course, support our sponsor, Medad101.com slash store.

0:49.7

All right, so the drug of the day today is oxycodone, which I have not covered yet, which is kind of

0:55.6

surprising to me as I was looking through my list.

0:58.6

Brand name of this medication, the extended release product is Oxycontin.

1:04.9

That's often a term you'll hear, a street term as well that you'll hear used.

1:10.3

This medication is an opioid and it is

1:13.9

oral only so comparing that to like morphine where we've got a ton of different dosage

1:20.9

forms oxycodone only comes as an oral agent at least that that's commercially manufactured. So like I mentioned,

1:31.3

it's an opioid analgesic, just a refresher mechanistically. This drug will bind opioid receptors

1:38.6

in the brain, central nervous system. And that's going to block those pain signals from getting to the brain. So essentially,

1:48.0

this doesn't allow the patient to perceive pain or at least perceive it to a significant extent.

1:56.1

They recognize that they may be hurt or injured, whatever the case may be, but their brain doesn't allow them

2:02.0

to perceive those pain signals coming to the central nervous system. So again, it doesn't really

2:08.1

reduce inflammation at the sight of the pain or whatever the case may be, but it actually just

2:14.9

blocks the signals.

...

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