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The Fat Emperor Podcast

Dave Feldman on LDL and All-Cause Mortality - Does Cholesterol Kill You?

The Fat Emperor Podcast

ivor cummins

Health & Fitness

4.8766 Ratings

🗓️ 15 June 2019

⏱️ 19 minutes

🧾️ Download transcript

Summary

 Dave Feldman with new data on LDL and....ALL CAUSE MORTALITY!

Does Cholesterol kill you?  Well look and see...!

TRANSCRIPT HERE:  https://thefatemperor.com/?p=2370&preview=true

INDEX/CONTENTS:

00:00 Mining NHANES Database for LDL and Mortality data 

02:30 Stratifying the data – to get the answer 

04:10 And the answer? Does higher LDL shorten your life? 

06:24 A discussion on “Reverse Causality” – could it confound? 

10:38` The confounding of it all – LDL is riddled with correlation to bad things  

13:15 What’s really going on with LDL 

15:51 More opportunities like this in the future – with more mining! 

Transcript

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0:00.0

Welcome to the Fat Emperor podcast. I'm your host, Ivor Cummins. We're supported by the Irish

0:08.4

Heart Disease Awareness charity, which advocates a simple CT scan to reveal your CAC score. So,

0:14.8

know your score and take action to prevent that premature heart attack. Everything you need to know

0:20.3

will be right here.

0:21.6

I'm here at Keto Salt Lake for a conference which just started today.

0:28.6

And I caught up again with Dave Feldman, who just gave a fascinating talk, again on LDL,

0:34.6

but with some very new data. So great to see again, Dave.

0:37.8

Yeah, likewise, Ivor. Thanks for having me.

0:39.8

Not at all. Always a pleasure.

0:41.8

Now, you had new data today because I know that we've always wondered about LDL being a problematic compound in the body.

0:50.3

And it seems there's been a lot of data over the last five or six years where when LDL is high,

0:54.9

but other things like HDL are high and triglycerides are low,

0:59.0

most of the data suggests there's no problem with LDL being high.

1:03.0

But today was different because you pulled databases of 50,000 people and you did a bit of analysis.

1:09.7

And the results were quite stunning.

1:11.6

So maybe if you start going through some of those.

1:13.6

Yeah, well of course, as you know, this has been a bit of a long history.

1:18.6

I've not been in the space quite as long as you have, but in the time that I have, I've been

1:22.6

interested in how these markers play out, particularly as you were kind of mentioning outside of LDL,

1:29.3

HDL cholesterol, and triglycerides. And it's always been a bit frustrating because, as you know,

1:34.3

all we pretty much can do is trade studies between each other. If we ourselves are not,

1:39.3

you know, researchers with that data on hand, it's hard for us to look through raw data, but we're engineers, right?

...

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