Change Your Brain, Change Your Pain with Dr. Daniel Amen

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

Personal Journals, Health & Fitness, Society & Culture

4.9 • 3.7K Ratings

🗓️ 2 September 2025

⏱️ 70 minutes

🔗️ Recording | iTunes | RSS

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Summary

This week, Christina and Jamie are joined by Dr. Daniel Amen, a physician, double board-certified psychiatrist, and award-winning researcher. They discuss why pain can also live in your brain, the doom loop and how to get out of it, the cost of repressed emotions, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Hexclad - Find your forever cookware @hexclad and get 10% off at hexclad.com/messy #hexcladpartnerHoneylove: Save 20% Off Honeylove by going to honeylove.com/messy #honeylovepod AGZ - Start taking your sleep seriously with AGZ. Head to drinkag1.com/messy to get a FREE welcome kit with the flavor of your choice that includes a 30 day supply of AGZ and a free frother Calm - Calm has an exclusive offer just for listeners of our show– get 40% off a Calm Premium Subscription at calm.com/messy. This is an amazing value.

Transcript

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0:00.0	Hi, I'm Christina Applegate. And I'm Jamie Lynn Sigler. And this is messy.
0:10.5	The following message is brought to you by Novartis. Hi, I'm Jamie Lynn Sigler. When it comes to
0:20.4	relapsing MS treatments, your choice
0:22.4	matters. That's why talking to your doctor about your options is a big deal. But how do you know
0:27.0	what to ask? Figuring that out can be daunting. That's why I partner with Novartis to create
0:32.5	an MS treatment decision guide. It's packed with helpful info and questions for your doctor
0:37.2	to help make an
0:38.1	informed decision. Trust me, the more prepared you are, the more confident you'll feel. Download the
0:43.4	guide right to your phone, only at treatmentdecisionguide.com. Welcome to messy guys. We have such a wonderful episode for you today. Today we have,
1:00.6	who's been called the most popular psychiatrist in America. He's a board certified child and adult
1:06.5	psychiatrist and the CEO of Aman Clinics with 11 locations nationwide.
1:12.2	He's a 12-time New York Times best-selling author and researcher with over 90 published
1:17.5	scientific articles that have led to groundbreaking brain imaging research in multiple
1:22.5	fields.
1:23.1	With over 10 million social media followers, his mission is simply to end mental illness by creating a revolution in brain health.
1:31.5	His new book coming out this December in 2025 is called Change Your Brain, Change Your Pain,
1:37.6	where he reveals that pain is not just a body problem, but a brain problem.
1:42.8	He talks about how pain can rewire our brain, trapping it into
1:46.7	a vicious doom loop, keeping a person stuck in suffering, sadness, and stress. Well, guess what?
1:53.9	No more. Please welcome to the show, Dr. Amen. Thank you so much for joining us.
1:59.8	It's my pleasure. Thank you.
2:01.5	I'm so excited because I can't wait to listen to everything you have to say because the brain,
	...

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