Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Derek Christensen.

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All right, let's get into the drug of the day today, and this is by request.

The drug is Brexpiprosol.

Brand name of this medication is Rexalti, and this medication is a second generation antipsychotic so from a mechanism of action

standpoint understand that antipsychotics will have action on dopamine receptors and specifically

dopamine two receptors.

Now, Brexprizol varies a little bit compared to most traditional antipsychotics in its mechanism of action.

So it is a partial agonist or has partial agonist activity for serotonin 1A receptors.

In addition, it's got partial agonist activity to those D2 receptors.

So again, this is agonist activity.

So partial agonist activity means so partial agonist activity,

means it stimulates that receptor to a certain extent, but also prevents or can help reduce the action of full agonist on those dopamine receptors.

So it can kind of limit the activity in being a partial agonist.

It also has some antagonist activity at 5HT2A receptors.

Again, 5HT stands for serotonin.

Just kind of another way to abbreviate that.

So if you see that in the literature, that's what that's referring to.

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