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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Propylthiouracil Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 15 December 2022

⏱️ 12 minutes

🧾️ Download transcript

Summary

In this podcast episode, I cover propylthiouracil pharmacology, adverse effect, drug interaction, and much more!



Propylthiouracil carries a boxed warning for hepatotoxicity which is a significant downside compared to the other agent in its class (methimazole).



What about dosing? I discuss why this medication has to be dosed multiple times per day.



Drug interactions aren't incredibly common with propylthiouracil but it can affect warfarin differently than most drug interactions. I discuss it further in this episode.

Transcript

Click on a timestamp to play from that location

0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

0:06.1

As always, go check out Real Life Pharmacology.com. We've got the free Top 200 study guide.

0:14.3

Great no-brainer to have if you're in pharmacology classes, taking board exams, or if you're just looking for a refresher.

0:21.3

So again, real-life pharmacology.com will have that.

0:25.2

Simply an email will get you access.

0:27.6

All right, the drug of the day today is propyl thio-eurosome.

0:33.3

Now, most of you, if you've heard of this drug, have probably heard it referred by its name PtU,

0:40.9

or the abbreviation PtU.

0:43.5

Brand names of this medication, halosil, and thyracill or two that I've heard.

0:50.1

But overwhelmingly, I've heard folks call it PtU.

0:54.2

So that's probably what you'll hear in your pharmacology classes

0:58.2

and or clinical practice depending upon where you're at.

1:02.8

So this medication is an antithyroid agent.

1:07.3

So, you know, in a broad scheme of things, think the opposite of levo thyroxin,

1:13.9

which is basically supplementing or adding thyroid hormone. So as you could expect,

1:20.4

if it's an antithyroid agent, it's going to be used to manage hyperthyroidism. Graves disease

1:26.4

being kind of a classic example here. Now keep in mind there

1:31.2

are other medical procedures and things we do to manage hyperthyroidism. So medication therapy

1:37.2

like propylophtyotio or so may not be used in that situation. However, it is an option if patients are unable to do the other procedures,

1:46.6

that type of thing, which I'm not going to go into too much detail here. I want to focus on the drug,

1:51.6

but keep in mind that that is certainly an option as well, depending upon the diagnosis and the

1:59.0

situation that we're in.

...

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