Apr 24 2026 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Science, Medicine, Health & Fitness

4.9 • 963 Ratings

🗓️ 24 April 2026

⏱️ 33 minutes

🔗️ Recording | iTunes | RSS

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Summary

PCSK9 inhibitors in high-risk diabetes without ASCVD, the CAAN-AF trial, conduction system pacing vs biventricular pacing, PFA and stroke, and therapeutic fashion infects expert consensus are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I VESALIUS-CV

VESALIUS-CV Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
JAMA Substudy https://jamanetwork.com/journals/jama/fullarticle/2847162

II How Best to Maximize CRT Benefit in Patients with AF

CAAN-AF Trial https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag206/8654625?searchresult=1
Role of AV Node Ablation: Meta-analysis of Observational Studies https://www.jacc.org/doi/10.1016/j.jacc.2011.10.891

III Stroke Rates in PFA vs Thermal Ablation

Comparative Safety of RF versus PFA for AF in a High-Volume US Medical Center https://esc365.escardio.org/Ehra-congress/sessions/18281

IV Five New CSP Studies Presented and Published

HeartSync-LBBP Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2845803
PhysioSync-HF Trial

https://jamanetwork.com/journals/jamacardiology/fullarticle/2845802

LEFT-BUNDLE-CRT Trial https://doi.org/10.1093/eurheartj/ehag225
Long-Term Follow-up of His-Alternative I Trial https://www.jacc.org/doi/10.1016/j.jacep.2026.02.016
LECART Trial https://esc365.escardio.org/Ehra-congress/sessions/17140

V New EP Training Document Published

Advanced Training Statement on Clinical Cardiac Electrophysiology https://www.jacc.org/doi/10.1016/j.jacc.2026.01.074

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Questions or feedback, please contact news@medscape.net

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.4	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:14.6	When every decision matters, you need trusted medical intelligence.
0:19.1	Medscape AI synthesizes peer-reviewed evidence and Medscape's expert validated content in seconds,
0:25.2	delivering clinically verified answers you can trust.
0:28.3	Join over 13 million Medscape members on the world's leading platform for clinicians.
0:33.7	Start using Medscape AI on the web or in the Medscape app.
0:37.7	Medscape AI, trusted medical intelligence.
0:41.1	Hi, everyone.
0:42.0	This is John Mandrola from the Heart.org, Medscape Cardiology,
0:46.0	and this is this week in cardiology for April 24th, 2026.
0:50.6	This week, PCSKDon inhibitors in patients with high-risk diabetes without atherosclerotic disease,
0:57.9	the CAN-A-F trial, conduction system pacing versus bi-V pacing, PFA and stroke,
1:05.2	and how therapeutic fashion can infect expert consensus statements.
1:10.2	Now, we've had two major heart rhythm meetings,
1:12.9	the ERA meeting and HRS, so forgive me for covering many rhythm-related topics this week.
1:18.9	But let me start with an important sub-study of the Vesalius CV-Outcomes trial of Evalukumab,
1:26.0	the PCSK-9 inhibitor versus placebo, in patients without prior
1:30.4	MI, but at high cardiovascular risk. Now, in the main basalis cardiovascular trial published in New
1:37.5	England more than 12,000 patients with atherosclerosis or diabetes, but without a previous
1:43.5	MI or stroke, who had LDL
	...

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