May 01 2026 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 1 May 2026
⏱️ 29 minutes
🧾️ Download transcript
Summary
Time to quadruple therapy, the disappointing AVANT GUARD trial, PFA risks, the TREAT-PVC trial, and NSTEMI care in the frail elderly are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Time to Quadruple Therapy in HFrEF
- Time to Quadruple Therapy After Diagnosis of HFrEF https://jamanetwork.com/journals/jamacardiology/fullarticle/2846899
II AVANT GUARD
PFA Bests Meds as First-Line Treatment for Persistent AF in Randomized Trial https://www.medscape.com/viewarticle/pulsed-field-ablation-bests-meds-first-line-treatment-2026a1000dsm
Pulsed Field Ablation of AF Disappoints in Setup for Success: AVANT GUARD https://www.medscape.com/viewarticle/pulsed-field-ablation-af-disappoints-setup-success-avant-2026a1000ddt
- AVANT GUARD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600929
- Persistent AF: Meta-analysis of Invasive Strategies 10.1016/j.ijcard.2018.11.127 External Link
III Speaking of Scary News on PFA – The TIFFANY Study
- Abstract - The TIFFANY Study https://www.heartrhythmjournal.com/article/S1547-5271(26)01747-9/fulltext
- Delayed Myocardial Ischemia and Malignant Arrhythmias After PFA https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.077983
- Alberto Alfie Comment https://x.com/ALFIEEP1/status/2050029151315189774?s=20
IV TREAT PVC Trial
- TREAT-PVC Trial https://doi.org/10.1016/j.jacep.2026.01.011
- TREAT-AF Study 2020 https://doi.org/10.1016/j.jacep.2019.11.008
V NSTEMI In Frail Older Patients
- SENIOR-RITA Trial https://www.nejm.org/doi/10.1056/NEJMoa2407791
- Subanalysis of Senior RITA Trial https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2847995
- Timing of Invasive Strategy in Patients With Non-ST-Elevation Acute Coronary Syndrome -- Meta-analysis https://doi.org/10.1016/S0140-6736(17)31490-3
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Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.4 | This podcast is intended for health care professionals only. |
| 0:08.8 | Any views expressed are the presenters own and do not necessarily reflect the views of WebMD or Medscape. |
| 0:14.6 | When every decision matters, you need trusted medical intelligence. |
| 0:19.1 | Medscape AI synthesizes peer-reviewed evidence and Medscape's expert validated content |
| 0:24.0 | in seconds, delivering clinically verified answers you can trust. |
| 0:28.3 | Join over 13 million Medscape members on the world's leading platform for clinicians. |
| 0:33.7 | Start using Medscape AI on the web or in the Medscape app. |
| 0:40.3 | Medscape AI, trusted medical or in the Medscape app. Medscape AI trusted medical intelligence. Hi everyone. This is John Mandrola from the Heart.org Medscape Cardiology |
| 0:46.3 | and this is this week in Cardiology for May 1st, 2026. |
| 0:50.3 | This week, time to quadruple therapy, the disappointing avant-garde trial, PFA risk, the treat |
| 0:59.3 | PVC trial, and non-stemmy care in the frail elderly patient. |
| 1:05.5 | The first thing to say is how beautiful it is here in spring in Kentucky. We've had sun and rain and the flowers are |
| 1:13.4 | amazing. Schools out today because it is Kentucky Oaks the day before the Kentucky Derby and |
| 1:19.4 | tomorrow our city is electric. Okay, time to quadruble therapy and hef ref. Jamal Cardiology has an |
| 1:27.4 | interesting observational study taken from the veterans database. |
| 1:31.3 | Joshua Jacobs is the first author of the study and is designed to characterize something I have not yet heard about. |
| 1:37.3 | The TTQ, or Time to Quadruple Therapy in Patients with Hefref. |
| 1:42.3 | Now the background here is obvious. |
| 1:44.8 | Patients with Hefref do better if they can take to four drug classes. Heartfire experts want us to move fast and |
| 1:51.3 | get these drugs on board as soon as possible. Of course, this is easier said than done in the real |
| 1:57.2 | world. Now, the idea of this look-back study was to look at the use of quadruple therapy, RAS inhibition |
... |
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