Apr 17 2026 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Science, Medicine, Health & Fitness

4.9 • 963 Ratings

🗓️ 17 April 2026

⏱️ 28 minutes

🔗️ Recording | iTunes | RSS

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Summary

SPIRIT-HF, another spironolactone trial in HFpEF; the ESSENCE imaging study of the drug olezarsen; the SirPAD trial in peripheral artery disease; and ultrasound-guided femoral venous access are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I ACC: SPIRIT-HF Trial

FINEARTS-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2407107
TOPCAT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1313731

TOPCAT Americas Trial https://www.ahajournals.org/doi/10.1161/circulationaha.114.013255

II A New Class of Lipid Lowering Drug Has a Dubious Debut At ACC

ESSENCE-TIMI 73b Imaging Study https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.080012
ESSENCE-TIMI 73b Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2507227
IMPROVE IT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1410489

III Drug-Coated Balloons Looked Quite Good in PAD interventions

Sirolimus-Coated Balloon Reduces Amputation Risk in Peripheral Artery Disease

https://www.medscape.com/viewarticle/sirolimus-coated-balloon-reduces-amputation-risk-peripheral-2026a1000a83

SirPAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600360

IV Another Vascular Story from the European Heart Rhythm Association

ULYSSES Trial https://doi.org/10.1093/eurheartj/ehag291
ULTRA-FAST Trial https://doi.org/10.1093/europace/eux175

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Questions or feedback, please contact news@medscape.net

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.8	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:14.6	When every decision matters, you need trusted medical intelligence.
0:19.0	Medscape AI synthesizes peer-reviewed evidence and Medscape's expert validated content
0:24.0	in seconds, delivering clinically verified answers you can trust.
0:28.3	Join over 13 million Medscape members on the world's leading platform for clinicians.
0:33.7	Start using Medscape AI on the web or in the Medscape app.
0:37.6	Medscape AI, trusted medical intelligence.
0:41.1	Hi, everyone.
0:42.0	This is John Mandrola from the Heart.org, Medscape Cardiology.
0:46.1	And this is this week in cardiology for April 17th, 2026.
0:51.7	This week, Spirit HF, another spirinoleinolectone trial and Hephe. The essence imaging study of the
0:59.3	triglyceride lowering drug Olazarcin, surpad trial and peripheral artery disease, and
1:05.9	ultrasound guided femoral venous access, a wonderful trial called Ulysses.
1:12.0	So first, a quick thank you to all those who came up to me at the European Heart Rhythm Association meeting in Paris.
1:17.3	It was really nice to hear that you listen to this podcast.
1:21.2	I say sorry to the 5K organizers as I just woke up with a bit of a cold and could not answer the bell on Monday morning.
1:29.6	Okay, first topic today is the Spirit HF trial.
1:33.3	Now, this is from the ACC meeting, and I look forward to this trial,
1:36.9	which was another test of spinterlactone in patients with Hep-Path.
1:41.1	The goal, of course, was to retest the America's subgroup of the Topcat trial, which was a 2014
	...

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