Apr 10 2026 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 10 April 2026
⏱️ 32 minutes
🧾️ Download transcript
Summary
Three imaging-guided PCI trials (two with surprising results), LDL targets, an oral PCSK9 inhibitor, and another beta-blocker withdrawal trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I IVUS-Guided PCI
- OPTIMAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600440
- IVUS-CHIP Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601521
- ILUMIEN IV Trial https://www.nejm.org/doi/10.1056/NEJMoa2305861
- DKCRUSH VIII Trial https://doi.org/10.1016/j.jacc.2026.01.081
II Ez-PAVE Trial — Low vs Very Low LDL-targets
Does Ez-PAVE Support 'Lower Is Better' for LDL-C? https://www.medscape.com/viewarticle/does-ez-pave-support-lower-better-ldl-c-2026a1000akx
- Ez-PAVE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600283
- 2026 ACC/AHA Lipid Guidelines https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423
III CORALreef AddOn
- CORALreef AddOn Trial https://www.jacc.org/doi/abs/10.1016/j.jacc.2026.03.036
- This Week in Caardiology 2-6-26 https://www.medscape.com/viewarticle/1003240
- CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
IV Another Post-MI Beta-blocker Withdrawal Study: SMART-DECISION
- SMART-DECISION Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601005
- ABYSS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.8 | This podcast is intended for health care professionals only. |
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| 0:37.6 | Medscape AI, trusted medical intelligence. |
| 0:41.0 | Hi, everyone. |
| 0:41.9 | This is John Mandrola from the Heart.org Medscape Cardiology, |
| 0:46.1 | and this is this week in cardiology for April 10, 2026. |
| 0:50.8 | This week, three, imaging-guided PCI trials, two with surprising results, |
| 0:58.6 | LDL targets, an oral PSK9 inhibitor, and another beta blocker withdrawal trial. |
| 1:05.8 | Let's start with the first Ivis guided PCI trials. |
| 1:10.2 | Ivis is intravascular ultrasound. Two trials presented at |
| 1:14.6 | ACC, both published in New England Journal of Medicine, failed to find benefit from this Ivis-guided |
| 1:19.9 | PCI. The optimal trial studied Ivis in Lefmane disease, and the Ivis CHIP trial enrolled patients with complex high-risk PCI. |
| 1:30.5 | I think what's most striking about this story is the enthusiasm for imaging amongst many |
| 1:35.9 | proponents who I watch online. You get the sense that imaging is the right thing to do if you are a good |
| 1:42.1 | cardiologist. Now, I'm not an interventionalist. I'm an |
| 1:45.9 | electrophysiologist, so I approach this from an evidence angle, and oh boy, is there an interesting |
... |
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