Apr 03 2026 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Science, Medicine, Health & Fitness

4.9 • 963 Ratings

🗓️ 3 April 2026

⏱️ 44 minutes

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Summary

John Mandrola offers an ACC recap of 5 big trials—Hi-PEITHO, PROTAVI, ORBITA-CTO, CHIPS-BCIS3 and CHAMPION AF

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Catheter Based Fibrinolysis of Pulmonary Embolism –Hi PEITHO

Fibrinolysis Treatment Validated in Large Trial for Acute Intermediate-Risk PE https://www.medscape.com/viewarticle/fibrinolysis-treatment-validated-large-trial-acute-2026a10009im
Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism (HI PEITHO) https://www.nejm.org/doi/full/10.1056/NEJMoa2516567
National Early Warning Score (NEWS) https://www.england.nhs.uk/ourwork/clinical-policy/sepsis/nationalearlywarningscore/

II PRO-TAVI trial

Deferral of percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation (PRO-TAVI) 10.1016/S0140-6736(26)00308-9 External Link
PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation (Notion 3) https://www.nejm.org/doi/full/10.1056/NEJMoa2401513

III ORBITA CTO Sham vs PCI for Angina Relief

Tightly Blinded Trial Confirms PCI Reduces Angina in Obstructive Occlusion https://www.medscape.com/viewarticle/tightly-blinded-trial-confirms-pci-reduces-angina-2026a10009ob

A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina - ORBITA-CTO https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027
ORBITA 1 10.1016/S0140-6736(17)32714-9 External Link
ORBITA 2 https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
DECISION CTO https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031313
EuroCTO https://doi.org/10.1093/eurheartj/ehy220

IV CHIPS BCIS3 Impella Supported High-Risk PCI

Adoption Before Evidence: CHIP-BCIS3 Humbles Impella https://www.medscape.com/viewarticle/adoption-before-evidence-chip-bcis3-humbles-impella-2026a10009jh

Left Ventricular Unloading in High-Risk PCI (CHIP BCIS3) https://www.nejm.org/doi/full/10.1056/NEJMoa2515704
Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock (DanGer Shock) https://www.nejm.org/doi/full/10.1056/NEJMoa2312572

V CHAMPION AF – Watchman vs DOAC in Patients With AF

CHAMPION-AF Trial Finds LAAC an Alternative for NOAC in Lower-Risk Patients https://www.medscape.com/viewarticle/champion-af-trial-finds-laac-alternative-noac-lower-risk-2026a10009ij
Six Reasons Why CHAMPION-AF Should Not Change Practice https://www.medscape.com/viewarticle/six-reasons-why-champion-af-should-not-change-practice-2026a10009i7

Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation (CHAMPION AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2517213
Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (CLOSURE AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2513310

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Questions or feedback, please contact news@medscape.net

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.8	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:14.6	When every decision matters, you need trusted medical intelligence.
0:19.0	Medscape AI synthesizes peer-reviewed evidence and Medscape's expert validated content
0:24.1	in seconds, delivering clinically verified answers you can trust.
0:28.6	Join over 13 million Medscape members on the world's leading platform for clinicians.
0:33.9	Start using Medscape AI on the web or in the Medscape app.
0:40.3	Medscape AI, trusted medical intelligence.
0:44.7	This is John Mandrola from the heart.org Medscape Cardiology,
0:49.4	and this is this week in cardiology for April 3, 26.
0:57.3	This week, a big ACC recap number one, and I'll talk about five of the biggest trials,
1:04.9	high patho, pro-tavi, Orbita CTO, Chips B-CIS3, and Champion AF.
1:11.5	Let's start with the interventional treatment of PE, the high-itho trial, which was actually the first late-breaking clinical trial.
1:15.0	And at ACC, I sat up front during the presentation.
1:18.6	High-Pizzo was the first trial.
1:20.6	I was there to hear Champion, which was to follow, and I wasn't listening that actively,
1:25.5	but what I did hear was a pretty jubilant presenter and even more enthusiastic trial discussants.
1:32.4	Quote, a new era in PE care I heard in my ears.
1:37.4	I made note and I said, I'm going to look under the hood that is trial.
1:40.7	Well, what follows is my look under the hood? Even if you aren't a P.E. interventionalist,
1:47.3	you're probably not. I'm not. There are really great trial lessons to be had here.
	...

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