Mar 27 2026 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 27 March 2026
⏱️ 26 minutes
🧾️ Download transcript
Summary
Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
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I Early AVR
- RECOVERY Trial at 10 Years https://www.nejm.org/doi/full/10.1056/NEJMoa2511920
II Major Bleeding with Amulet and Watchman in JAMA Cardiology
- Amulet IDE Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2847047
- 5-year Results From Amulet IDE https://www.jacc.org/doi/10.1016/j.jacc.2024.10.101
III ACC Preview
Mandrola's Top 4 Trials from ACC 2026: Details Matter
https://www.medscape.com/viewarticle/mandrolas-top-4-trials-acc-2026-details-matter-2026a10008ti
- CHIB-BCIS3 Trial https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013367
- Champion-AF Protocol https://doi.org/10.1016/j.ahj.2023.05.022
- ORBITA-CTO Protocol Paper https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1172763/full
- SPIRIT-HF Clinical Trials.gov https://clinicaltrials.gov/study/NCT04727073
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Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.7 | This podcast is intended for healthcare professionals only. |
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| 0:41.1 | Hi, everyone. |
| 0:42.1 | This is John Mandrola from the Heart.org Medscape Cardiology, |
| 0:46.4 | and this is this week in cardiology for March 27, 2026. |
| 0:51.8 | This week, early aortic valve replacement and aortic stenosis, left atrial appendage |
| 0:57.3 | reclusion in JAMA cardiology, and a big ACCC preview. First up, let's talk about early |
| 1:05.2 | aortic valve replacement. New England Journal of Medicine published long-term follow-up of the |
| 1:10.3 | South Korean recovery trial |
| 1:12.0 | of early aortic valve replacement for his conservative care in patients with severe aortic stenosis. |
| 1:19.6 | Now, the first publication of recovery was in 2020, and it had six years of follow-up. |
| 1:24.0 | This one has 12 years of follow-up. |
| 1:26.5 | Now, right there, you're squinting, right? Because |
| 1:28.5 | most patients with aortic-cidosis are near 80 years old. But that's one of the many interesting |
| 1:34.5 | things about this trial. The mean age of patients was approximately 64 years. The primary endpoint was |
... |
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