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Public Health On Call

997 - The New Drug Igniting a Withdrawal Crisis

Public Health On Call

The Johns Hopkins Bloomberg School of Public Health

News, Health & Fitness, Medicine

4.6 • 644 Ratings

🗓️ 15 January 2026

⏱️ 14 minutes

🧾️ Download transcript

Summary

About this episode:

Medetomidine, a veterinary sedative similar to xylazine, is appearing more frequently in drug supplies in Maryland, Delaware, and Pennsylvania—and the withdrawal symptoms are debilitating. In this episode: Addiction medicine specialist Jordan Nahas-Vigon details the risks facing people who use drugs and why it's so difficult to quit.

Guests:

Dr. Jordan Nahas-Vigon is a primary care doctor with Johns Hopkins Medicine who specializes in addiction medicine.

Host:

Dr. Josh Sharfstein is distinguished professor of the practice in Health Policy and Management, a pediatrician, and former secretary of Maryland's Health Department.

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Transcript information:

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Transcript

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0:00.0

Welcome to Public Health On Call, a podcast from the Johns Hopkins Bloomberg School of Public Health,

0:05.9

where we bring evidence, experience, and perspective to make sense of today's leading health challenges.

0:16.3

If you have questions or ideas for us, please send an email to public health question at jhh.edu.

0:23.8

That's public health question at jhhu.edu for future podcast episodes.

0:31.0

Hey listeners, it's Lindsay Smith Rogers.

0:33.1

Today, a new threat in the drug supply, Meditomedeen.

0:36.8

Dr. Jordan Nahas-Vigon is an addiction medicine

0:39.8

specialist at Johns Hopkins Bayview Hospital. She talks to Dr. Josh Starstein about this chemical,

0:45.2

what it's doing in the drug supply, the terrible withdrawal that it causes, and how it's

0:49.5

threatening public health. Let's listen. Dr. Nejas-Vigone, thank you so much for joining me here on public

0:55.9

health on call. Thank you for having me, Josh. We're going to talk about metatomedeen, but before we

1:02.1

get to that new drug that is appearing in cities across the country, I want to have you

1:09.5

introduce yourself to our audience. Sure. I am a

1:13.9

primary care doctor. I work at Johns Hopkins Bayview Medical Center and I do general primary care

1:21.0

as well as specializing in addiction medicine. So that includes seeing patients in clinic who have substance use disorders and seeing

1:30.4

patients in the hospital, both on our addiction medicine unit and on the addiction medicine

1:35.8

console unit. So you take care of a lot of patients with addiction patients who may be using

1:42.3

actively drugs like fentanyl, for example?

1:45.9

Yes, we see it a lot.

1:48.3

And so when did you first hear of metatomede?

1:51.5

So I think that I first heard about it maybe back in the summer of 2024, but it quickly

1:59.0

sort of went in one ear and out the other. I did not think of it as a lasting concern. In October of 24, we admitted a patient to our addiction medicine unit who had the worst opioid withdrawal I'd ever seen.

...

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