SEXY SCIENCE CORNER! What differentiates athletes late in endurance events like marathons and ultras? Why can some athletes train the same, pace the same, fuel the same--yet have different results? The answer may be found in the emerging study of "fatigue resistance." Fatigue resistance does not have a set definition, but is generally classified as the extent of performance deterioration late in events, often unexplained by normal physiological profiling while fresh. This episode takes a deep dive into some of the sexiest science and training theory of how the brain and nervous system influence late-race fatigue. We take you on a thrilling ride featuring neurotransmitters, genetics, metabolic variables, and much more, with the goal of highlighting what contributes to physiological breakthroughs over time. It concludes with 10 training theories you can put into practice to accomplish some big, scary goals.

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