4.5 • 1.5K Ratings
🗓️ 19 August 2025
⏱️ 104 minutes
🧾️ Download transcript
Dr. Robert Lustig is a neuroendocrinologist, New York Times bestselling author and Professor of Pediatric Endocrinology.
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Show notes:
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0:00.0 | Coming up on today's show. |
0:02.1 | Insulin is a bad guy. |
0:04.6 | I can't say it any simpler than that. |
0:08.1 | Yes, glucose is bad too. |
0:09.6 | I'm not saying it's not. |
0:11.0 | Insulin is worse. |
0:12.4 | Insulin is associated with all of the diseases of metabolic syndrome. |
0:16.6 | Type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, cancer, dementia. |
0:21.1 | And why are we insulin resistant? Because our mitochondria is screwed. |
0:24.0 | Mitochondria are fat. So the lower the fat that you're eating, the less well your mitochondria |
0:29.5 | would work actually cause the insulin resistance. This concept of calories is useless. |
0:35.6 | It's essentially garbage. Calories come from bomb calarimeters, |
0:39.9 | or mitochondria are not bomb calibrometers. So there's leptin deficiency, there's leptin resistance. |
0:45.0 | Ultimately, the brain sees the same thing, not enough leptin. But leptin deficiencies a total of 14 |
0:50.4 | people in the world. Leptin resistance is about 4 billion people. 14 people, 4 billion people. |
0:56.8 | Which you think you have. You got to fix the leptin resistance. So what causes the leptin resistance? |
1:06.0 | Rob, why is excess insulin a problem and how much is too much? Why is excess insulin a problem and how much is too much? |
1:11.9 | Why is excess insulin a problem? |
1:14.3 | So let's talk about what insulin is. |
1:18.6 | Insulin is a hormone. |
1:21.1 | It's made in one place, works in another. |
1:24.0 | It's made by the beta cells of the pancreas, |
... |
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