4.5 • 1.5K Ratings
🗓️ 24 June 2025
⏱️ 95 minutes
🧾️ Download transcript
Dr. Nicholas Norwitz is a researcher-educator whose mission is to “Make Metabolic Health Mainstream.”
He graduated Valedictorian from Dartmouth College, majoring in Cell Biology and Biochemistry. Nick then completed his PhD in Metabolism at the University of Oxford. Next, he went on to Harvard Medical School and completed his MD.
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Show notes:
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0:00.0 | Coming up on today's show. |
0:02.1 | Mark Bell, some of you might know him, started the sugar diet. |
0:05.0 | He's a big time influencer, historically low-carb keto. |
0:08.5 | I ended up losing a lot of weight doing low-carb keto, and he started posting about the sugar |
0:12.9 | diet. |
0:13.3 | He's saying he's losing fat and not losing muscle and his exercise performance is fantastic. |
0:17.6 | I'm going to have to relate this to a new human controlled trial that was published |
0:21.2 | in one of my favorite journals Nature Metabolism. Basically what they did in this study is they took |
0:25.4 | lean, healthy med, so men generally in their 20s, BMI around 25. They put them on a protein |
0:30.3 | restricted diet that was high carb and generally low fat. So over five weeks, what ended up happening |
0:35.2 | is a remarkable 19% increase in total energy |
0:39.2 | expenditure without changes in physical activity. 5754 more calories burned when they were eating a high |
0:45.4 | carb, low protein, low fat diet. It's quite remarkable. What I think it is is an opportunity |
0:50.8 | to use a viral fad diet to understand really cool metabolism that underlies |
0:56.3 | not just that, but other ways in which we can look at diets, even ketogenic diet. |
1:01.0 | So I think it's a really cool trend. |
1:02.6 | I'm not going to do it myself, but I hope people try to understand it rather than just dismiss it as stupid. |
1:08.9 | Nick, it's coming up on a year since we last chatted. |
1:12.3 | In that time frame, in the research realm, in the metabolic health realm, what has got |
1:20.0 | you most excited? |
1:21.4 | First of all, thanks for having me back, Jesse. |
1:23.4 | I can't believe it's been a year. |
... |
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