649: Why “in range” lab results aren’t the solution to longevity | Florence Comite, M.D.

The mindbodygreen Podcast

mindbodygreen

Alternative Health, Health & Fitness

4.5 • 2.1K Ratings

🗓️ 10 May 2026

⏱️ 53 minutes

🔗️ Recording | iTunes | RSS

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Summary

"What we don't know CAN really hurt us, " says Florence Comite, M.D. Comite is a Yale University School of Medicine and National Institutes of Medicine trained physician-scientist, endocrinologist, and the leading voice in the field of precision medicine and healthy longevity. She was founder of the first global women only health center at Yale three decades ago and is founder of the Comite Center for Precision Medicine & Healthy Longevity in 2005, in New York, with satellite offices in Palo Alto and Miami Beach. Her new book, Invincible: Defy Your Genetic Destiny to Live Better, Longer, was published by Little, Brown Spark in April 2026. Catch this week’s episode of mindbodygreen podcast, created in sponsorship with Toyota. For vehicles designed for all that life has to offer, check out the 2026 RAV4, Sienna, Highlander, and Grand Highlander. Hop in, turn on the episode, and enjoy every mile. 00:00 - Aging starts in your thirties 01:55 - The decline of testosterone 07:29 - How genetics dictate aging 10:08 - Increasing testosterone 12:30 - Hormone therapy 17:59 - A DHEA story 20:37 - Metabolic markers 26:11 - Using a continuous glucose monitor 33:13 - Heart medication & testing 36:06 - Personalized medicine & prevention 39:56 - The Alzheimer's spectrum 42:38 - Genetic variables & testing 49:00 - The trouble with AI in medicine For more about Comite, visit her website: https://florencecomite.com/ Buy her book here: https://a.co/d/0cnOvaH8 We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Welcome to the My Buddy Green podcast. I'm Jason Wacob, founder and co-CEO of My Buddy Green and your host.
0:07.3	This podcast was created in sponsorship with Toyota. At My Buddy Green, we believe in a well-lived life is one you share with people you love. The right vehicle makes that possible.
0:16.8	The 2026 Toyota Rav4 is built for all of life's moments, big and small.
0:21.9	Need more room for the crew? The Toyota Highlander comfortably seats up to eight.
0:26.0	For bigger plans, the Toyota Grand Highlander offers spacious comfort and smart storage.
0:31.3	When families at the center of it all, the Toyota Sienna brings flexibility to support every chapter.
0:36.7	No matter where you're headed, the right vehicle turns travel time into together time.
0:41.6	Learn more at Toyota.com.
0:43.5	People are the destination.
0:48.7	What if everything you've been told about aging is wrong?
0:52.3	Today's guests have spent 30 years proving exactly that.
0:55.7	Dr. Florence Comete is a Yale-trained endocrinologist where she's also launched one of the
1:00.5	country's first women's health programs. She is a pioneer in precision medicine and what she calls
1:05.8	our end-of-one medicine. The idea that your lab work, your genes, and your health trajectory is
1:10.7	uniquely yours,
1:12.1	and it's one of our favorite topics here at Mind Buddy Green. She is also an author of the new book,
1:16.7	Invincible, which lays out framework for reversing biological aging and extending health span,
1:22.5	not just lifespan. In today's show, we get into the five biomarkers. She says are abnormal in virtually everyone
1:28.9	as they age, why free testosterone matters for everyone starting in their 30s, what optimal
1:34.8	glucose metabolism actually looks like, and why your genes are not your destiny. Let's dive in.
1:43.8	You argue aging starts decades before symptoms.
1:48.4	What are some of the earliest signs that we completely miss?
	...

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