298. The Neuroscience of Antidepressants Part 2: The Glutamate Hypothesis
Do You F*cking Mind?
Alexis Fernandez-Preiksa - Neuroscientist and Mindset Coach
4.9 • 914 Ratings
🗓️ 4 February 2024
⏱️ 24 minutes
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Summary
In part 2 of my Neuroscience episodes about antidepressants I’m diving into the Glutamate Hypothesis.
I chat about the role of the glutamatergic system within the brain in helping us to better understand why some people don’t respond well to the first line of treatments, such as SSRIs.
I’m also diving into treatment resistant depression, electro convulsive therapy (ECT) neuroplasticity and transcranial magnetic stimulation.
LINKS:
- Listen to Part 1 of this series The Neuroscience of Anti-Depressants: The Monoamine Hypothesis at https://pod.fo/e/21783a .
- Read the paper ‘Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization’ accessible via PUBMED https://tr.ee/glutamatergic-paper .
- Listen to episode 50. Stress on the brain and how to reverse its effects at https://pod.fo/e/1f8306 .
- Listen to episode 257 my episode on Ketamine as a treatment for depression here https://bit.ly/Dyfm-ketamine.
- Join the DYFM Facebook Group https://bit.ly/dyfm-group .
- Follow @dyfmpodcast on IG
- Follow @alexispredez on IG
- Follow @listnrentertainment on IG
CREDITS
Host: Alexis Fernandez
Executive Producer & Editor: Elise Cooper
Digital Producer: Zoe Panaretos
DYFM Social Producer: Shania Magua
Managing Producer: Sam Cavanagh
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Transcript
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| 0:00.0 | A Listener Production |
| 0:03.9 | Please leave your message after the tone |
| 0:07.3 | Why am I jealous of my ex? |
| 0:09.7 | I am so stressed all the time |
| 0:11.7 | How do I get into a routine? |
| 0:13.3 | Is TikTok making me anxious? |
| 0:15.2 | I think I'm being manipulated. |
| 0:16.9 | Someone told me you could live with half a brain. |
| 0:19.4 | This is Do You Fucking Mind, Mindset Hacks for a Badass Life? |
| 0:23.3 | Hosted by me, Alexis Fernandez. |
| 0:26.3 | Hello everyone and welcome to the episode of today, which is the part two of my little |
| 0:32.6 | neuroscience of treatments for depression little series. |
| 0:37.1 | So last week I covered the first line of |
| 0:41.7 | defense when it comes to treatments for depression, which was all around the monoamine |
| 0:46.6 | hypothesis. So if you are somebody that's ever been on antidepressants or spoken to your doctor about getting on antidepressants, |
| 0:56.8 | they likely would have, the first thing they would have offered you is something along the |
| 1:00.5 | lines of an SSRI. |
| 1:03.2 | And then if that didn't work, trying other things like SNRIs and things like that. |
| 1:07.9 | But that's in my last episode. |
| 1:09.5 | In this episode, I'm talking about |
| 1:11.6 | other treatments for depression, which I'm focusing on the glutamate hypothesis and kind of |
| 1:19.9 | the glutamotogic system within how to treat depression. So there's a big difference between |
... |
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