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FoundMyFitness

#050 NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

FoundMyFitness

Rhonda Patrick, Ph.D.

Fitness, Depression, Foundmyfitness, Timferriss, Sleep, Diet, Longevity, Ketosis, Rhondapatrick, Kevinrose, Domdagostino, Health, Sauna, Nutrition, Medicine, Fasting, Healthspan, Mattwalker, Coldexposure, Lifeextension, Health & Fitness, Exercise

4.85.5K Ratings

🗓️ 13 November 2019

⏱️ 36 minutes

🧾️ Download transcript

Summary

In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age.
In this episode, you'll discover:
  • 00:00:00 - Introduction
  • 00:03:07 - Overview of NAD+, a source of cellular energy
  • 00:09:18 - NAD+ fuels PARP and sirtuin enzymes, promoting longevity
  • 00:12:37 - How can I raise NAD+ levels?
  • 00:17:03 - Can NAD+ boosters (NMN & NR) promote cancer growth?
  • 00:19:15 - Making sense of the research so far
  • 00:27:03 - Why not supplement with NAD+ directly?
  • 00:29:23 - Clinical trials investigating nicotinamide riboside are promising
  • 00:32:42 - Recap and concluding thoughts

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/nad-nr-nmn

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Transcript

Click on a timestamp to play from that location

0:00.0

Howdy folks! Today is a special episode. Rather than giving you an interview, in this episode,

0:06.0

I'd like to take a shot at instead giving you guys the full lay of the land on a topic we've

0:11.0

continually touched on across multiple episodes, which is all things NAD. We've brushed up against

0:17.4

this topic in many interviews, the most obvious of which being the conversation I had with Dr.

0:22.5

Davidson Claire. But also others like a prior episode with Dr. Eric Verden, both great episodes

0:29.6

which you should definitely listen to. Those episodes were, however, conversations, which means

0:34.8

that in each case, while certainly educational, they weren't necessarily structured to strictly

0:40.3

be a primer. Today's episode is different. Instead, my goal in this one is to structure it in a way

0:46.7

as to give you an overview that can lay the framework towards your understanding, the relevance,

0:51.7

the questions that still need to be answered by the field, and also just my sort of concluding

0:56.6

thoughts when it's all said and done. Not only on NAD, but also on the so-called NAD boosters,

1:03.5

which are the NAD precursors, nicotinamide riboside, and nicotinamide mononucleotide. Before we kick

1:09.6

this thing off, a quick mention about this episode. It's actually been out for almost an entire week.

1:14.9

Surprised? You shouldn't be. This is one of the new elements of the engine that keeps found my

1:19.8

fitness not only running, but thriving, by offering a few solid concrete perks for supporting

1:25.7

members. I am able to keep this podcast free, grow my team, and actually make free found my fitness

1:32.1

better than ever before. Premium members now get a pretty sweet list of benefits, including

1:36.9

a members-only early access feed that also gives periodic exclusive content. Free updates on

1:42.5

genetic reports when they come out. Twice per month, a member's only email summary of some of the

1:47.4

most interesting research that jumped out at me. This next one is a big one for audio-only listeners,

1:52.6

a PowerPoint presentation with all the videos on screen graphics. Get the benefits of the video

1:58.3

without the video. Take my last podcast with Dr. Davidson Claire, for example, 150 slides.

...

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