#049 Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

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Rhonda Patrick, Ph.D.

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4.8 • 5.5K Ratings

🗓️ 6 November 2019

⏱️ 82 minutes

🔗️ Recording | iTunes | RSS

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Summary

David A. Sinclair

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.

Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, you'll discover:

00:00:00 - Introduction
00:17:59 - Caloric restriction, fasting, and exercise activate sirtuin longevity genes
00:21:47 - Boosting NAD+ levels reduces sirtuin loss with age
00:23:03 - Resveratrol extends sirtuin activation
00:27:36 - NAD+ resets epigenetic aging clocks
00:31:54 - Yamanaka factors reprogram adult cells into stem cells
00:46:48 - Resveratrol is a xenohormetic compound
00:55:35 - Resveratrol improved cognitive function in Alzheimer's disease
00:58:03 - NR and NMN improve cognitive function
01:06:19 - NMN delays aging in multiple organs
01:01:22 - Challenges of translating animal research

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/david-sinclair

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Transcript

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0:00.0	Welcome back friends. I know that many of you have been waiting a long time for this release,
0:04.6	so I can't tell you how genuinely excited I am to finally get to share today's episode with you.
0:09.7	This episode features Dr. Davidson Claire.
0:12.8	David is a professor in the Department of Genetics at Harvard Medical School and co-director of Paul F. Glenn Center for Biological Mechanisms of Aging.
0:20.7	David is also a co-author of the book titled,
0:23.9	Lifespan, Why We Age and Why We Don't Have To, which is out now and available on Amazon.
0:30.1	In this book, David goes into great detail about many of the topics we actually discuss in this episode,
0:36.0	particularly his theory of aging known as the informational theory of aging.
0:40.8	So that is a really great way to learn more about what we talk about today.
0:45.2	I thoroughly recommend checking out his book.
0:48.0	In this episode, David and I discuss how caloric restriction fasting and exercise increased levels of a molecule called NAD,
0:55.8	and how this activates SirTuins, a family of enzymes involved in longevity.
1:00.8	In addition to activating SirTuins, how NAD is essential for mitochondrial metabolism and function,
1:06.7	but also how it's required for repairing damage to DNA by activating an enzyme called PARP.
1:12.1	We discuss how NAD levels and SirTuins activities decrease with age and how animal studies suggest
1:17.8	that raising cellular NAD levels can trick the body into thinking it is younger.
1:22.8	How plants produce compounds that activates SirTuins pathways in plants in response to stress,
1:28.6	and in turn, the compounds activate beneficial pathways like the SirTuins pathway in humans,
1:34.4	a phenomenon called xenohormesis.
1:37.6	How Resveratrol is a xenohormetic compound and is produced when great plants are stressed,
1:42.9	either in response to fungus or lack of water.
1:46.3	How Resveratrol enhances the binding of SirTuins to NAD, thus making SirTuins more easily activated
	...

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