Your Microbiome, GLP-1 & Next-Generation Probiotics | Dr. Colleen Cutcliffe
The Gabby Reece Show
Dear Media
4.8 • 954 Ratings
🗓️ 9 March 2026
⏱️ 76 minutes
🧾️ Download transcript
Summary
What if your metabolism, cravings, immune system — even your hormones — are being shaped by your gut?
In this episode of The Gabby Reece Show, Gabby sits down with microbiome scientist and Pendulum co-founder Dr. Colleen Cutcliffe to break down the real science behind gut health — beyond the buzzwords.
From premature birth and early antibiotic exposure to GLP-1, estrogen, cravings, and perimenopause, this conversation connects the dots between your microbiome and nearly every major system in your body.
If you’ve ever thought:
“Why am I gaining weight when nothing changed?”
“Why am I suddenly sensitive to foods?”
“Is this just aging… or something else?”
“Are GLP-1 drugs the only option?”
This episode will shift how you think about your body.
In This Episode, We Cover:
Why the microbiome is connected to all 11 organ systems
How early antibiotic use may affect long-term metabolic health
The truth about GLP-1 — and how your body produces it naturally
Why Akkermansia is considered a “keystone strain”
Gut health and perimenopause: what’s really happening
Estrogen, menopause, and emerging microbiome research
Why cravings may not be about willpower
How stress, aging, and travel deplete your gut
Fecal microbiome transplants — what they are and why they matter
How to rebuild a resilient gut (without extremes or shame)
Key Takeaway
The goal isn’t perfection.
It’s resilience.
A strong, diverse microbiome helps your body handle stress, hormonal shifts, aging, and even dietary slip-ups. And unlike your genetics — your gut can change.
Start with food.
Use tools wisely.
Pay attention to your body.
Connect with Dr. Colleen Cutcliffe
Website: https://pendulumlife.com
Instagram: @pendulumlife
Dr. Cutcliffe on Instagram: @drcolleencutcliffe
Connect with Gabby
Website: https://gabbyreece.com
Instagram: @gabbyreece https://www.instagram.com/gabbyreece
YouTube: The Gabby Reece Show https://www.youtube.com/@GabbyReece
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Transcript
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| 0:00.0 | The following podcast is a Dear Media production. |
| 0:03.8 | Hi, everyone. |
| 0:04.8 | Welcome to the show. |
| 0:05.6 | I'm your host, Gabby Reese, and let's face it, none of us have the answers. |
| 0:09.5 | But that's why I think having the conversations with some of the smartest people, whether |
| 0:13.2 | it's in health and fitness, relationships, parenting, even business, gives us an opportunity |
| 0:18.8 | to take complex ideas, simplify them, and put them in our |
| 0:22.7 | day-to-day lives and make them more manageable, easier, and more fun. Remember to subscribe and |
| 0:29.1 | like, and it's all an experiment. Colleen Kotloff, welcome to the show. We've seen each other maybe twice in the last two months. |
| 0:43.2 | I know. Are you sick of me yet? |
| 0:44.6 | No. I'm so excited because now, I mean, we did a panel together. It was very fancy, Hallie Berry, who you work with. |
| 0:51.6 | It's hard to say her name and not want to go into a song, but we didn't |
| 0:55.5 | get to maybe go as deep about gut health. And I think, you know, it's maybe been a few years now |
| 1:02.6 | where everyone's like, oh, your gut health, the gut, the good bugs, the bad bugs, microbiome, |
| 1:08.3 | I think if we could actually get into why does the microbiome even matter? |
| 1:14.2 | Because sometimes I feel like when we're surrounded by the information, we actually don't hear |
| 1:19.1 | it anymore or understand, well, why would I need that to be important? |
| 1:23.5 | Yeah. Yeah. Well, thanks so much for having me and for digging in because I think there's a lot of |
| 1:28.5 | information and new information and a lot of misinformation. So happy to dig into that together. |
| 1:33.5 | And I think why the microbiome matters. Well, it didn't matter for a long time. Nobody really thought |
| 1:38.9 | about it very much. There were a lot of sayings about your gut instinct, your gut feelings, trust your gut. |
| 1:43.2 | And there's always been this |
... |
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