So which NAD boosting supplement is best?

There's no clear standout, as hardly any of the preclinical effects found in the lab

have translated into evidence of human clinical benefit.

Perhaps this failure is to be expected, given the complexity of NAD physiology, with its juggling

of multiple precursors, production pathways, and recycling routes.

The bottom line is that it's just too early to say if NAD booster supplementation will

ever live up even a fraction of the hype.

Many more, larger, and longer-term studies are necessary to establish safety and efficacy.

The problem is that because N-A, NAM, N-R, and NMN are all natural products,

they can't be patented, so the money for well-designed clinical trials is not as available. The reason there have been comparatively more trials done on NR than NMN is that

patents were originally issued for NR before being invalidated as unpatentable.

Perhaps blindly overloading the system with NAD precursors is not the best way to go about NAD restoration.

The body seems too smart to allow such blunt incursion to affect tissue levels.

Maybe these supplements are just profit-making distractions for more natural approaches.

Broadly, there are three main ways to increase NAD plus levels.

Increasing the supply of NAD precursors is just the first.

The other two are having the body make more by activating NAD synthesizing enzymes

or have the body use less via an inhibition of excess

NAD degradation.

The primary determinant of NAD synthesis is the enzyme NAMPT.

An abundance of NAMPT tends to decrease with age in human muscle, dropping steadily by

about 40 percent between

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