What causes cardiovascular disease (Lipid Series - Part 1) | Dr Thomas Dayspring

The Proof with Simon Hill

Simon Hill

Nutrition, Education, Self-improvement, Health & Fitness

4.9 • 3.1K Ratings

🗓️ 13 March 2023

⏱️ 122 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode #251. Cardiovascular disease is one of the biggest killers in the Western world, and it’s vital that we understand cardiovascular health in order to improve lifespan and healthspan. In this episode, I sit down with Dr Thomas Dayspring for Part One of a three-part deep dive into cardiovascular disease and blood lipids. In this introductory episode, we examine how our body absorbs lipids and transports them throughout the body – and what happens when it goes wrong. Specifically, we discuss: Intro (00:00) Turning a family heartache into a mission (05:12) Atherosclerosis and the role of lipids (14:52) Lipoproteins & cholesterol transport and recycling (28:01) Cholesterol's role in lipoproteins (54:00) Is ApoB a more accurate marker of cardiovascular risk? (58:38) Endothelial transcytosis of lipoproteins (1:07:10) LDL aggregation (1:16:42) LDL particle retention and inflammation (1:23:15) Difference between veins and arteries (1:28:55) Atherosclerosis and genetics (1:30:22) High-fat diets and cholesterol (1:44:01) Fiber and cholesterol absorption (1:48:14) Outro (1:57:48) The best place to connect with Dr Thomas Dayspring is on Twitter, @DrLipid. Learn more about Dr Dayspring’s career and current work on LinkedIn. Discover more insights and supporting studies in the full show notes. To assist with the digestibility of this content, Dr Dayspring, my team, and I have included extensive illustrations and graphs to the video format of these episodes. If you are visually inclined, you can watch these episodes on The Proof YouTube channel. Even if you prefer listening through audio the first time, I highly recommend coming back for a second pass with the video versions. These episodes are investments into a healthier future. Get your copy of the Lipid Series Cheat Sheet at theproof.com/lipidseries. This comprehensive resource provides valuable insights on assessing your risk, preventing, and treating atherosclerotic cardiovascular disease (ASCVD), the leading cause of death worldwide. The PDF not only highlights key learnings from the 3-Part Lipid Series but also includes a 1-week meal plan designed to promote healthy cholesterol levels. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary two-week meal plan and high protein Plant Performance recipe book

Transcript

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0:00.0	Hey there, I've got a very quick message to share with you before we jump into the
0:07.0	episode.
0:08.0	Let's keep this under 30 seconds, shall we?
0:11.5	This episode is proudly brought to you by Amille.
0:13.7	Amille is a plant-based wellness company focused on formulating evidence-based supplements
0:18.2	to optimize our health.
0:20.0	I personally take Amille's essential aid multi-nutrient to how I start my day, which contains
0:25.0	eight essential nutrients in the right forms and dosages to perfectly complement a plant-rich
0:30.1	diet.
0:31.1	Amille offers no magic pills or hyperbolic claims, just good quality supplements that
0:36.3	we can trust.
0:37.3	To check out Amille and get 10% off your first order, visit theproof.com forward slash
0:42.5	friends.
0:43.5	I'll pop a link to that in the show notes.
0:49.0	If apobeme measurement in the blood exceeds a certain level, there are more apob particle
0:56.3	circulating than the liver is clearing.
0:59.7	And as that number goes up and up and up, the particles are obviously not being cleared
1:04.2	by the liver.
1:05.5	So where do they go?
1:07.3	We have miles and miles of endothelium on our arteries, so they just pick the nearest
1:12.4	artery and they crash it.
1:14.7	And the apobeparticle carrying cholesterol, step one of atherogenesis, it passes through
	...

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