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Dr. Joseph Mercola - Take Control of Your Health

Vitamins K and A Aid Brain Health

Dr. Joseph Mercola - Take Control of Your Health

Briana Mercola

Alternative Health, Health & Fitness

4.61.6K Ratings

🗓️ 13 November 2025

⏱️ 8 minutes

🧾️ Download transcript

Summary

  • Researchers created vitamin K analogues that cross the blood-brain barrier more effectively, which eventually turn into the bioactive form, menaquinone-4 (MK-4)
  • Higher levels of MK-4 in brain tissue correlate with 17% to 20% lower dementia risk and reduced Alzheimer's-related brain damage
  • Vitamin A's active form, retinoic acid, enhances synaptic plasticity and memory formation, with deficiencies linked to cognitive impairment and neuropsychiatric disorders
  • Both vitamin K and retinoic acid signaling naturally decrease with aging, contributing to reduced neurogenesis and weakened memory circuits in older adults
  • Consume K2-rich fermented foods, pair with healthy fats for absorption, combine with vitamin D3 and magnesium, and include vitamin A sources like leafy greens

Transcript

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0:00.0

What if the vitamins you overlook each day are quietly shaping your memory, your focus, and your long-term risk of dementia?

0:07.0

Welcome to Dr. Mercola's cellular wisdom. Stay informed with quick, easy-to-listen summaries of our latest articles, perfect for when you're on the go. No reading required.

0:17.0

Subscribe for free at Mercola.com for the latest health insights.

0:26.3

Hello and welcome to Dr. Mercola's cellular wisdom. I'm Ethan Foster, and today we're examining how vitamins K and A influence your brain. What recent studies reveal about

0:31.5

vitamin K analogs that reach your neurons, why higher levels of MK4 and brain tissue

0:37.0

align with lower dementia risk, and how

0:39.6

vitamin A's active form, retinohic acid, supports synaptic plasticity and memory.

0:45.5

I'm here to guide the discussion and keep it practical for you.

0:49.0

I'm Alara Sky, and I'll help unpack the findings so you can understand what they mean

0:53.7

for your cognition as you age.

0:56.5

We'll connect the lab work to clear actions you can take, centered on food choices and smart combinations,

1:02.6

without drifting beyond what the research describes.

1:06.1

Researchers recently modified vitamin K molecules and tested whether these analogs could cross the

1:11.4

blood-brain barrier and convert into the bioactive form your brain stores, Menequinone 4, or

1:18.5

MK4. Among the 12 versions they engineered, one, referred to as compound 7, stood out because

1:25.9

it reached the brain after oral intake and was metabolized

1:29.1

into mK4. That matters because many substances never make it past the brain's tight security,

1:35.2

which is a major hurdle for therapies aimed at neurons. The same compound didn't just arrive.

1:40.9

It acted. In neural precursor models, it promoted the shift from immature cells to fully

1:47.0

differentiated neurons capable of signaling. It also activated nuclear receptors tied to gene expression,

1:54.0

including retinohic acid receptors, and the steroid and xenobiotic receptor.

2:00.0

Modeling suggested stronger binding to the M-G-L-U-R-1 receptor,

...

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