Hey, all, welcome back to the Real Life Pharmacology podcast.

I am your host pharmacist, Eric Christensen.

Thank you so much for listening today.

As always, go check out real life pharmacology.com.

We've got a free top 200 study guide.

It's 31 page PDF, a lot of content within there.

And, of course, a lot of important things you're going to see

throughout your career as a practicing health care professional, as well as throughout school

in pharmacology courses and final exams, board exams. So definitely go take advantage of that

free resource at real-life pharmacology.com. With that, let's get into the drug of the day today, and that is Vardinifil.

You might notice that ending, Vardinifil, similar to sildenafil,

tadal is another example.

So this is a PDE5 inhibitor that is used for erectile dysfunction primarily.

Lvivra is the brand name here.

Mechanistically, how does this medication work?

So with the process of male sexual stimulation, nitric oxide plays an important role.

And this nitric oxide release activates guanolite cyclase to increase cyclic gmp.

So cyclic gmp is an important mediator in helping to create the male erection.

So what Vardinifil does is preserves cyclic gmp by inhibiting phosphodiasterase 5.

Okay, so this is basically an enzyme that breaks down cyclic gmp.

So by blocking PDE5, we're increasing the amount of cyclic gmp, which helps with erection and things

of that nature. So that's how the drug primarily works and helps with erectile dysfunction.

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