4.8 • 688 Ratings
🗓️ 17 June 2025
⏱️ 42 minutes
🧾️ Download transcript
In this episode, Dr. Jockers and Dr. William Hsu dive into how nourished fasting can reduce insulin resistance, activate autophagy, and slow aging. They discuss how the fasting mimicking diet triggers cellular repair while still providing nourishment.
Learn how nutrient-sensing pathways like mTOR and IGF-1 influence metabolic health and why modern eating habits may accelerate aging. Dr. Hsu explains how short-term fasting can promote healing by tapping into the body’s natural survival mechanisms.
Discover how to apply nourished fasting in your life with the ProLon protocol and why a few cycles a year can significantly improve your healthspan.
In This Episode:
00:00 Introduction to the Fast Mimicking Diet
02:49 Interview with Dr. William Hsu: Metabolic Health and Fasting
04:48 The Science Behind Fasting and Cellular Healing
06:49 The Evolutionary Perspective on Fasting
09:22 Understanding Nutrient Sensing Pathways
14:33 The Nobel Prize-Winning Research on Autophagy
17:44 The Concept of Fasting Mimicking Diet
21:25 Exploring the Benefits of Fasting Mimicking Diet
22:01 The Science Behind Fasting and Systemic Health
23:22 The Role of Lifestyle Medicine
24:16 Understanding Digestive Health and Stomach Acid
26:10 Hormetic Stress and Health Benefits
27:16 Clinical Research on Fasting Mimicking Diet
31:32 Practical Application of Fasting Mimicking Diet
32:43 Personalized Programs for Health Conditions
35:22 The Future of Lifestyle Medicine
40:54 Final Thoughts and Call to Action
Still cooking with seed oils? That could be fueling inflammation. I’ve switched to Paleovalley’s 100% grass-fed beef tallow—it’s rich in CLA, packed with flavor, and stable at high heat. It’s one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order.
Heartburn doesn’t mean you have too much stomach acid—it usually means you don’t have enough. That’s why I recommend Just Thrive’s Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you’re supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%.
"Autophagy is your body’s self-cleaning cycle—and most people never turn it on."
~ Dr. Jockers
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Resources:
Get 15% off Paleovalley Beef Tallow: paleovalley.com/jockers – Use code JOCKERS
Save 20% on Just Thrive Digestive Bitters: justthrivehealth.com – Use code JOCKERS
Connect with Dr. William Hsu:
Prolon 5 Day Fasting Mimicking Diet: https://prolonlife.com/
Connect with Dr. Jockers:
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Facebook – https://www.facebook.com/DrDavidJockers
YouTube – https://www.youtube.com/user/djockers
Website – https://drjockers.com/
If you are interested in being a guest on the show, we would love to hear from you! Please contact us here! - https://drjockers.com/join-us-dr-jockers-functional-nutrition-podcast/
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0:00.0 | Now we're saying, for example, multiple cycles of the fasting-making diet can reduce insulin |
0:05.9 | level, can reduce insulin resistance, can help to drive belly fat loss. |
0:12.0 | So central fat decreases while preserving your body composition, enhancing your body composition. |
0:18.5 | Hello and welcome to the Dr. Jockers' functional nutrition podcast, the show designed to give |
0:26.0 | you science-based solutions to improve your health and life. I'm Dr. David Jockers, doctor of natural |
0:32.7 | medicine, and creator of Dr.Jockers.com. And I'm the host of this podcast. |
0:38.6 | I'm here to tell you that your body was created to heal itself. |
0:42.4 | And on this show, we focus on strategies you can apply today to heal and function at your best. |
0:48.8 | Thanks for spending time with me. |
0:50.7 | And let's go into the show. |
0:53.7 | Well, if you've been listening to this podcast for any like the time, you know, you cannot |
0:58.0 | cook or use seed oils. These things are so toxic. They're in so many different things. I'm |
1:03.0 | talking about canola oil, corn oil, soybean, safflower, cotton seed oil. One of the best things you |
1:08.0 | can do for your health is throw out the vegetable oils or the seed oils. What are good cooking oils? Well, you can certainly use things like olive oil. One of the best things you can do for your health is throw out the vegetable oils or the |
1:10.9 | seed oils. What are good cooking oils? Well, you can certainly use things like olive oil, |
1:15.1 | coconut oil, but one of my absolute favorite cooking oils for its flavor and its health benefits |
1:20.8 | is beef tallow. In particular, 100% grass-fed and finished beef tallow. And that's why I love |
1:27.4 | Paleo Valley's new 100% grass-fed and finished beef tallow. And that's why I love paleo-vallies, new 100% grass-fed |
1:30.3 | and finished beef tallow. It's loaded with conjugate linoleic acid, which studies show |
1:34.9 | has a variety of benefits, including supporting a healthy immune system and metabolism. CLA has been |
1:40.9 | shown to help boost fat burning. Also, the healthy fats that are in tallow help you |
1:45.6 | absorb fat soluble vitamins like vitamin A, D, E, and K. And tallow is very stable under high |
... |
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