Unlocking Health Through Your Genetic Code: Healing from Veganism, Chronic Pain & Stressors - Chris Masterjohn : 1090
The Human Upgrade: Biohacking for Longevity & Performance
Dave Asprey
4.6 • 7.4K Ratings
🗓️ 21 September 2023
⏱️ 81 minutes
🧾️ Download transcript
Summary
Today, we welcome back a guest from the early days of this podcast, fellow former vegan and esteemed researcher and scientist, Chris Masterjohn. Chris Masterjohn earned his PhD in Nutritional Sciences from the University of Connecticut, and has worked as a postdoctoral research associate and Assistant Professor of Health and Nutrition Sciences.
In 2016, he transitioned to entrepreneurship. These days, Chris conducts independent research, consults, develops information products, and creates free content to help people improve their health.
Chris is dedicated to sharing practical principles from complex science, and to the pursuit of truth and continuous learning. He's a biohacker from before the word “biohacking” came to be, appearing on episode 16 of this podcast when I was just getting that movement started, because he not only pays attention to how stuff works in the world and academic research, but he hacks his own body. I've always liked the way he thinks mechanistically about biology, nutrients, and what to eat.
In this conversation, we talk about how to recover from veganism and reverse the effects of oxalates, highlighting the long term health impacts of the vegan diet. His own self experimentation lately is of particular interest to me as he’s been exploring the intersection of genetics and mitochondrial health to heal niche health conditions and even quell extreme fears or stressors.
We also talk about the link between energy metabolism and psychological trauma, chronic pain and oxalate overload, and even explore the potential dangers of methylene blue from his latest 58 page research paper breaking down the importance of correct dosing.
If you’re a true biohacker, you’re going to love this deep dive into how minerals and metabolism play a huge role in our biology.
(03:47) Genetic Optimization: A New Approach to Healing Chronic Pain & Disease
• How his perspective on nutrition has changed since our first episode
• The extreme effects veganism had on his health
• Using genetics research to find solutions to rare health issues
• The role of AI in diagnosing health conditions—now and in the future
• Focusing on mitochondria as the root cause to heal health issues
• Access his program: chrismasterjohnphd.com
• What will reverse the anti fertility trend?
• The psychological rewiring required to heal chronic disease states
• Lowering your stress response with GABA and hierarchical exposure therapy
• How energy metabolism and psychological trauma symptoms are related
(32:08) Recovering from Veganism & Oxalate Overload
• Can you do veganism well?
• Addressing the impact of plant toxins and oxalates
• The link between chronic pain and oxalate overload
• How to reverse the effects of oxalates
• The use of biotin to clear oxalates and dosing suggestions
• Read: Toxic Superfoods by Sally Norton
• Oxalate dumping symptoms explained
• Advice for recovering vegans
• Read: Le Chatelier's principle
• Viome: viome.com
(01:04:09) Methylene Blue: Potential Dangers & Dosage Recommendations
• The dangers of combining methylene blue with ayahuasca and psychedelics
• Research conclusions on methylene blue dosing
• How methylene blue can impact people with Alzheimer’s
• Side effects of combining methylene blue with SSRIs
• Using methylene blue to help allergy sufferers
• ED as a side effect of methylene blue
Resources
Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
Website: chrismasterjohnphd.com
Facebook: facebook.com/chrismasterjohn
X: twitter.com/ChrisMasterjohn
Rumble: rumble.com/user/chrismasterjohn
YouTube: youtube.com/user/chrismasterjohn
Telegram: t.me/chrismasterjohnphd
GETTR: gettr.com/user/chrismasterjohn
Podcast: Everything You Need To Know About Saturated Fat & Cholesterol with Chris Masterjohn #16
Podcast: Nicotine, the Perfect Psychotropic? Dr. Paul Newhouse # 494
The Human Upgrade is produced by Crate Media.
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Transcript
Click on a timestamp to play from that location
| 0:00.0 | You're listening to the human upgrade with Dave Asprey. |
| 0:06.0 | Formerly, Bulletproof Radio. Hi. Today it's going to be a really really cool interview because we're at somewhere |
| 0:26.7 | around episode 1080 depending whenever this comes out and I asked a guy who I really should have had on before now, |
| 0:36.0 | someone I mentioned in my last book in A Smarter Not Harder, |
| 0:40.0 | who was guest number 17 on the show in the very early days of |
| 0:45.2 | podcasting and he is a PhD nutritional science holder from back then actually in 2012 and has been an assistant professor of |
| 0:56.8 | health and nutrition at Brooklyn College. I've always liked the way he thinks mechanistically about biology, about nutrients, about what to eat. |
| 1:07.0 | He's a biohacker from before the word biohacking came to be, which episode 17 when I was just getting that movement started because he not only pays |
| 1:19.5 | attention to how stuff works in the world and academic research and all that, but he hacks his own body, which is particularly interesting. |
| 1:27.0 | So there are many people, for instance, Dr. nicotine from Vanderbilt, who's been on the show studying nicotine as a reversal agent for Alzheimer's |
| 1:36.7 | disease, not smoking but actually nicotine for 30 years and has never tried nicotine one time in his life. |
| 1:43.3 | I'm like, how can this be? |
| 1:45.6 | So Chris Master John is the opposite of that. |
| 1:48.0 | He's like, well, I tried it, didn't really work, |
| 1:50.5 | so I did all the research and I wrote a 58 page paper on it in my spare time |
| 1:54.9 | Well protesting against government intervention in our health and things like that so Chris you stood up like a boss during the last three hellish years and really just put |
| 2:06.5 | hard science out there which I appreciate I want to call you out to say thanks and |
| 2:09.8 | just welcome you back to the show. Thank you so much, Dave. That means a lot. |
| 2:14.0 | I mentioned, I believe it was your reference on minerals and food, and |
| 2:18.7 | smarter or not harder because I've written a lot about the importance of minerals in food and you just put together |
| 2:25.8 | a great resource there that had like the right information all put together that's actually |
| 2:30.6 | very hard to find as a researcher. |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Dave Asprey, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Dave Asprey and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.