TWiV 998: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 8 April 2023

⏱️ 52 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode White House COVID adviser calls on doctors to combat medical information (STAT) Adeno-associated virus type 2 in US children with acute severe hepatitis (Nature) Genomic investigations of unexplained acute hepatitis in children (Nature) Surveillance of SARS-CoV-2 at the Huanan Seafood Market (ChinaXiv) Vaccine effectiveness against hospitalization among pediatric SARS-CoV-2 cases (PLOS) Effectiveness of BNT162b2 after extending the series dosing interval in children (Nature) Prevalence and characteristics associated with post–COVID-19 condition (JAMA) Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals (Nature) Replication-competent-attenuated vaccine sCPD9 elicits immunity to SARS-CoV-2 variants (Nature) Fc-γR antibody functions needed for SARS-CoV-2 variant protection via vaccination (Nature) COVID-19 convalescent plasma utilization in the United States (CID) FDA authorizes Gohibic injection for the treatment of COVID-19 (FDA) IFX-1 antibody vs. supportive care for severe COVID-19 patients (Lancet) Vilobelimab therapy for COVID-19 critically ill patients on mechanical ventilation (Lancet) Triple combo therapy for relapsed SARS-CoV-2 in immunocompromised patients with antivirals and antibodies (CID) Neutralizing antibody response breadth to SARS-CoV-2 tied to Long COVID presence (medRxiv) Neurological Long COVID pathogenesis and potential therapies (Journal Cells) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 998 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

Click on a timestamp to play from that location

0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is TWIV, this week in virology, episode 998 recorded on April 5th,
0:19.3	2023. I'm Vincent Racken-Yellow and you're listening to the podcast, all about viruses.
0:26.8	Joining me today from New York, Daniel Griffin. Hello, everyone. Wow, 998 Daniel, that's
0:34.9	something because when the pandemic started, we just hit 600 as we said last time. So,
0:40.7	I'm amazed at how many episodes we have in, but I don't think we're going to make 2,000.
0:47.0	400 plus episodes since the pandemic started. That's amazing. And yeah, the next clinical update
0:54.8	will be part of TWIV 1000. Probably small parts, I'll save up some stuff for like what, TWIV 1000 and 1.
1:03.7	Yeah, we have to skip next week's clinical update to synchronize for a thousand. Otherwise,
1:09.5	it would be well messed up, but this is tomorrow, Friday, we're doing the last regular TWIV,
1:16.8	that'll be 999. And then we'll do a thousand and then we'll get back to the next thousand. Yeah.
1:24.8	Okay, let me jump right into my quotation. I've got a lot to say today, I seem always to,
1:31.6	but let's go right with the quotation. Let not anyone pacify his conscience by the delusion that
1:38.3	he can do no harm if he takes no part and forms no opinion. Bad men need nothing more to compass
1:44.9	their ends than that good man should look on and do nothing. He's not a good man who without a
1:50.5	protest allows wrong to be committed in his name and with the means which he helps to supply,
1:56.4	because he will not trouble himself to use his mind on this subject. And that's John Stewart Mill.
2:03.5	And I'd like to update this with people, but I agree with the sentiment. But it brings me
2:09.5	right into the article. If we don't, others will. White House COVID advisor calls on doctors to
2:16.1	combat a vacuum of medical information published in stat by Elizabeth Cuny. You know, I always
2:23.6	want to rename these things, right? You know, it shouldn't be just doctors, you should be doctors,
2:28.9	scientists, and the like. But I'll just read one of the parts of this article. What we have seen
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Vincent Racaniello, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Vincent Racaniello and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.