TWiV 992: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 18 March 2023

⏱️ 32 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment. Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Clearance of vaccine-derived poliovirus following remdesivir therapy for SARS-CoV-2 infection (Frontiers) SARS-CoV-2 exposure in Norway rats from New York City (mBio) Clinical characteristics and outcomes of children with SARS-CoV-2 Infection in Korea (JKMS) Exhaled breath aerosol shedding of SARS-CoV-2 variants (CID) Outpatient treatment of COVID-19 and the development of Long COVID (The Lancet) Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) Risk of venous thromboembolism in nonhospitalized patients with COVID-19 (JAMA) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 992 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.3	From microob TV, this is TWIV, this week in virology episode 992 recorded on March 15th,
0:19.6	2020-23. I'm Jensit Racken Yellow and you're listening to the podcast all about viruses.
0:27.7	Joining me today from Arizona, Daniel Griffin. Hello, everyone.
0:34.4	It just doesn't roll off the tongue like New York Daniel, sorry.
0:38.8	And live from Arizona. Let's get right into it because I'm taking a break from being on spring
0:46.1	break with my daughters and my wife and I will start with our quotation. New knowledge is the
0:52.0	most valuable commodity on earth. The more truth we have to work with, the richer we become.
0:58.6	And that's from Kurt Vonnegut. Jump right into polio. This is like one of those marvel cross
1:05.7	overs. So the article case report clearance of longstanding immune deficiency associated vaccine
1:12.5	derived polio virus infection following Remdesivir therapy for chronic SARS-CoV-2 infection
1:19.0	was published as a case report in frontiers in immunology. So we previously discussed the
1:24.7	prolonged shedding in some people of vaccine derived polio virus after oral vaccination with the
1:31.9	Sabentipolio vaccine as opposed to the injected inactivated sock type polio vaccine.
1:38.6	Here are the authors describe a case of a 50 year old man with common variable immune deficiency
1:46.3	persistently infected with a neuro virulent vaccine derived type to polio virus following vaccination
1:54.3	in childhood. This immunodeficiency associated vaccine derived polio virus infection had proven
2:01.4	resistant to multiple prior attempts at treatment with human breast milk, ribo virus,
2:07.2	and oral administration of a normal human pooled immunoglobulin product. His infection
2:13.2	subsequently resolved after 12 days of treatment with Remdesivir. So I will note this was 12 days
2:20.2	of IV Remdesivir being given for an acute COVID infection. Vincent, any thoughts?
2:26.4	I think it's very exciting. I think it was bound to happen with so many people infected and being treated
	...

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