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This Week in Virology

TWiV 967: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.82.2K Ratings

🗓️ 24 December 2022

⏱️ 51 minutes

🧾️ Download transcript

Summary

In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immunological dysfunction persists for 8 months following SARS-CoV-2 infection (Nature) Prevalence of SARS-CoV-2 and Influenza coinfection and clinical characteristics (CDC) WHO estimates of excess mortality associated with the COVID-19 pandemic (Nature) Reconsideration of anti-nucleocapsid IgG antibody as a marker of SARS-CoV-2 infection (OFID) Impact of SARS-CoV-2 variants on inpatient clinical outcome (CID) Clinical features and burden of post-acute sequelae of SARS-CoV-2 infection (OFID) Similar SARS-CoV-2 Ct value distributions in samples from symptomatic children (JPIDS) Early estimates of bivalent mRNA vaccine effectiveness in preventing COVID-19 (CDC) Effect of Nirmatrelvir/Ritonavir vs placebo on COVID-19─Related hospitalizations (OFID) COVID-19 Convalescent Plasma outpatient therapy to prevent outpatient hospitalization (MedRxiv) Bacterial co-infection and empirical antibiotic therapy in patients with COVID-19 (OFID) Association of time to surgery after COVID-19 infection (JAMA) Demonstration of stable clusters of symptoms in long COVID (OFID) Paxlovid patient eligbiliity screening checklist (FDA) Longitudinal analysis of T cells in COVID-19 survivors with post-acute sequelae (OFID) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 967 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0

This week in virology, the podcast about viruses, the kind that make you sick.

0:10.4

From micro TV, this is twiv this week in virology, episode 967 recorded on December 22nd, 2022.

0:21.8

I'm Vincent Racken-Ello and you're listening to the podcast all about viruses.

0:26.0

Joining me from New York, Daniel Griffin.

0:29.9

Hello, everyone. I'm glad to have you back because it was too noisy in Uganda.

0:35.3

It was hard to say. You know, like that first night, like out there in the storm and trying to use my iPhone

0:45.6

and then that, you know, the couple other times when I was recording, like up in the mountains on the DRC

0:51.6

border, what like a few kilometers away from where the ISIS insurgents came across the line.

0:56.5

It was just people do appreciate that you do this remotely. And I think we couldn't have done

1:03.8

this five years ago, probably. The tech wasn't there. So it was really remarkable that we can do this.

1:10.8

So anytime it's fine, we can try it always because people need to keep up with their

1:15.6

clinical information. Yeah, I think Lori Garrett and I were chatting when there was that

1:21.7

event at the incubator about one time she had some satellite uplink and, you know, just,

1:27.5

yeah, just things have gotten a little bit easier. So I shouldn't complain. I'll just dive malaria.

1:35.7

But all right, let me get right into it. No one is useless in this world who lightens the

1:41.9

burdens of another. And that's Charles Dickens. And it seems to me that quoting Dixins works with

1:47.6

so many celebrating Christmas throughout the world. So this will drop, I guess, on Christmas Eve. So

1:55.1

Merry Christmas to those of you celebrating. And actually, we are in the middle of Hanukkah,

2:00.4

actually. So for the youngest who listen, I think we have some very young listeners. Remember,

2:04.8

it's not like your birthday. Don't blow out the candles. All right.

2:08.5

All right. Let me start with an article, immunological dysfunction persist for eight months following

2:15.5

initial mild to moderate SARS-CoV-2 infection published in nature immunology. I have to say,

...

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