Hello everybody. We're going to record a session of this week in virology. So you might hear some of the same questions repeated, but it's okay because many other people are going to hear it.

You might get defenances.

Well, that would be interesting if you got the finances. Which all right.

This week in virology, the podcast about viruses, the kind that make you sick.

From ESCV 22, this is twiv this week in virology, a special episode recorded on September 7th, 2022.

I'm Vincent Draken yellow and you're listening to the podcast all about viruses. My guest today at this meeting is professor of clinical neurology at the University of Edinburgh.

Richard Knight, welcome to twiv.

I give you.

Do I get the pronunciation right?

Of Edinburgh.

It was Falsenkinson.

Well, thank you for joining me.

We are at the last session of today's meeting.

We are going to talk about variant CJD and BSE.

But before we do that, we need a little background for our audience, which is not our audience today because they've already heard it.

So let's start with the basics. What is a preion disease?

A preion disease as far as unconcerned is a disease in which there is a disease of the brain associated with the deposition of abnormally folded preion protein in the tissue.

Right.

And we heard from Stan Prusener that there can be different proteins involved, right?

Well, I think that's the difficulty. That's an expanded description of preion disease.

Because of course the neurodegenerative diseases like Parkinson's, Alzheimer's disease, which people may be very much more familiar with than CJD.

They also appear to have rather similar pathological underpinnings and they're associated with the deposition of abnormally folded proteins in the brain, although different proteins.

...