TWiV 949: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 29 October 2022

⏱️ 45 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Progress toward Poliomyelitis eradication (CDC) Polio by the numbers (JID) Influenza & COVID-19 vaccination coverage among health care personnel (CDC) Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID) Receipt of first & second doses of JYNNEOS vaccine (CDC) Distinguishing SARS-CoV-2 persistence and reinfection (CID) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Novavax triggers potent neutralization of Omicron sub-lineages (bioRxiV) Association between physical activity & vaccination protective effect (BMJ) PAXLOVID patient eligibility screening checklist (FDA) COVID-19 outcomes in solid organ transplant recipients who received monoclonal antibodies (Transplantation) Omicron BA.2.75.2 exhibits escape from neutralizing antibodies (bioRxiV) Tocilizumab vs. Baricitinib in hospitalized patients with severe COVID-19 (CMI) Dr. Griffin’s treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 949 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.6	From Microbe TV, this is TWIV, this week in virology, episode 949 recorded on October 27, 2022.
0:22.2	I'm Vincent Racken Yellow and you're listening to the podcast all about viruses joining me today from New York.
0:30.7	Daniel Griffin. Hello everyone and joining us today from Hawaii Vincent.
0:37.5	Yes, I'm in the big island today where it is 11 a.m. and for you Daniel is just the end of the day, right?
0:44.7	I wish it was the end of the day. It's only 5 p.m.
0:47.0	a lot more, lots more day to go. All right, I'll start with my quotation.
0:53.6	Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying
1:01.5	and greed. If people all over the world would do this, it would change the earth.
1:07.4	And that was William Faulkner and this is from the speech he gave when asked by his daughter,
1:11.7	Jill, to speak at her high school graduation university, high school, in Oxford, Mississippi, 1951.
1:20.1	A huge Faulkner fan and actually sort of was reminded of my interest in Faulkner by a recent book I
1:27.4	read, Breathless, right? David Kwaneman is also a big Faulkner fan. Faulkner had a bad influence on
1:34.6	me. Why is that Daniel? Well, you know, I had read the unvanquished right before high school graduation.
1:41.9	So I decided, you know, much like the character I could cut my hair with a pocket knife.
1:46.1	Who needed a fancy barber? So yeah. No, I love Faulkner. I love the way his sentence is just
1:55.2	go on and just how much it's about the language. But all right, let's get right into it.
2:01.4	Paulio, an interesting week for polio. I think I can say that as our listeners may or may not have
2:08.7	heard, Dr. Janelle Ruth, the CDC's team leader for domestic polio announced that they are in
2:16.4	discussions with New York State and New York City colleagues about the use of the novel oral polio
2:22.3	virus to stop the current transmission of polio here in New York. Yeah, I'm not sure that's going
2:28.7	to happen. But anyway, there was an article. I've been around you too much, Vincent.
	...

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