TWiV 943: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 8 October 2022

⏱️ 43 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support MicrobeTV with a Spike t-shirt at Vaccinated.US Multi-National Monkeypox outbreak (CDC) Mutation of the Monkeypox Virus (Nature) Occupational infection of Healthcare workers with Monkeypox (CDC) Rates of Monkeypox cases by vaccination status (CDC) Protection of SARS-CoV-2 natural infection against reinfection (CMI) PAXLOVID patient eligibility screening checklist (FDA) Paxlovid reduces COVID19 hospitalizations & deaths (EPIC) Paxlovid rebound in COVID19 (NEJM) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Dr. Griffin’s treatment guide (pdf) Contribute to Floating Doctors fundraiser at PWB Letters read on TWiV 943 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is Twiv, this week in virology episode 943 recorded on October 6, 2022.
0:22.2	I'm Vincent Racken, yellow, and you're listening to the podcast all about viruses.
0:26.8	Joining me today from New York, Daniel Griffin.
0:32.0	Hello, everyone.
0:33.6	So Daniel, you heard Paul Offit. What do you think?
0:36.4	Paul Offit, if you're listening. Paul Offit's wife, if you're listening, you should give him
0:41.6	only go on Twiv. Because what I worry is on Twiv, his presentation was reasonable.
0:48.8	There was a really good discussion. I think it would be very hard to take what he had to say
0:53.8	wrong. I don't think you're going to end up with FDA, advisor, recommending against boosters.
0:59.7	You're going to get the message, which is measured. It's thoughtful.
1:05.4	And I really agree with a lot of what Paul Offit has to say. It's that we would love if we could
1:10.4	just have a blanket recommendation for everyone. And that's what the CDC sort of has to do.
1:15.7	But I think it's a little bit more challenging. And he went through a few scenarios, I think.
1:20.2	If you're 30 years old and you got three shots already and you had an infection in June,
1:26.8	should you be rushing out to get an Omicron booster? I'm not sure that that's going to do very much.
1:32.5	But on the other hand, I think Paul was clear on this, is that if you're over 65 or, and maybe he
1:38.5	should have mentioned this a little more, I noticed in the comments, or you have things that make
1:43.1	you high risk. There's younger individuals that have medical issues and you know, compromise.
1:48.4	Yeah, those people, the decision to get a booster is much more straightforward. I think that I
1:55.2	actually thought it was really good, but you can't put it in a nutshell. You got to listen to the
1:59.6	whole thing. Vincent, what did you think? You were there. I think, well, first of all,
	...

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