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This Week in Virology

TWiV 884: Cytokines and viral mimicry

This Week in Virology

Vincent Racaniello

Virology, Twiv, Pathogen, Virus, Microbe, Vincent, Microbiology, Medicine, Science & Medicine, Infectious, Racaniello, Infection

4.8 β€’ 2.2K Ratings

πŸ—“οΈ 3 April 2022

⏱️ 122 minutes

🧾️ Download transcript

Summary

Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2. Hosts: Vincent Racaniello and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) SARS-CoV-2 ORF8 mimics IL-17 (mBio) Letters read on TWiV 884 Timestamps by Jolene. Thanks! Weekly Picks Amy – Ben Franklin by Ken Burns Vincent – Thoughts on a second booster: Offit and Krause/Borio Listener Picks Philip – History of Clemson Blue Cheese Jack – Pipeline and A Special Report on Polio Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Transcript

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0:00.0

This week in virology, the podcast about viruses, the kind that make you sick.

0:10.3

From microbe TV, this is twiv this week in virology episode 884 recorded on April 1st, 2022.

0:21.5

I'm Vincent Racken-Yellow and you're listening to the podcast all about viruses.

0:25.6

Joining me today from New York, Amy Rosenfeld.

0:31.1

Love Vincent, how are you today?

0:32.7

It's April 1st.

0:34.7

So it's April full of day.

0:36.7

Maybe that's why we have nobody else with us.

0:40.5

That's it. Nobody else could make it today.

0:42.7

It's so fortunate, but it's fine. We are in good hands here.

0:46.5

First paper is from cell reports, asthmatic bronchial smooth muscle increases

0:53.2

rhino virus replication within the bronchial epithelium.

0:56.7

This is from a group in a variety of places in France.

1:00.6

Pulling S. Dev is the first author and then Thomas Trian and Patrick Berger to co-coresponding

1:08.3

authors. And I thought this would be interesting because Amy works on rhino viruses and

1:17.2

rhino viruses are major contributors to induction of asthma.

1:25.5

So asthma, of course, is an airway disease.

1:28.8

Very common, 60-20% of Western European countries have asthma.

1:34.6

And viral infection of the epithelium in the bronchi has been implicated.

1:41.1

80% of asthma exacerbations in children and adolescents and 60% in adults.

1:45.6

And in each case, rhino virus was the dominant viral pathogen causing 60% of all virus

1:52.0

induced asthma exacerbations.

...

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