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This Week in Virology

TWiV 882: Elispot on about T cells and lipids

This Week in Virology

Vincent Racaniello

Virology, Twiv, Pathogen, Virus, Microbe, Vincent, Microbiology, Medicine, Science & Medicine, Infectious, Racaniello, Infection

4.82.2K Ratings

🗓️ 31 March 2022

⏱️ 109 minutes

🧾️ Download transcript

Summary

Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Understanding T cell responses during COVID-19 (Science Immunol) IL-1 and IL-1ra are keys to inflammation after RNA vaccination (Nature Immunol) Letters read on TWiV 882 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Covid restrictions prevented dengue in hundreds of thousands of people in 2020 Vincent – Scotch Dual Lock 250 Reclosable Fastener Listener Picks Erin –JWT Preparation and Xploration Outer Space Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Transcript

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0:00.0

This week in virology, the podcast about viruses, the kind that make you sick.

0:10.4

From micro TV, this is TWIV, this week in virology, episode 882 recorded on March 29th, 2022.

0:21.3

I'm Vincent Racken Yellow, and you're listening to the podcast all about viruses,

0:25.6

joining me today from Madison, New Jersey, Brienne Barker.

0:30.1

Hi, it's great to be here. It is cloudy and 35 Fahrenheit. Winter has made a little bit of a comeback recently.

0:40.1

We had snow even yesterday. It's freezing. Yeah, it is. It's freezing here. It's totally crazy.

0:47.7

It's one degrees and cloudy here. I had to break out my old winter coat, but I think it's going to warm

0:55.2

up, which is nice. I think so too. Hopefully, this may be the end of winter.

1:01.5

Yeah, that would be good. I'm ready for a little warmer weather. Me too.

1:05.6

Well, today we have just me and Brienne, which we've done this before, I think, right?

1:12.0

Yes, we have.

1:13.9

And so I picked a couple of immunology heavy papers. So I hope you enjoyed them.

1:21.1

The first one, our snippet actually, was suggested by Bonnie Offit.

1:28.1

I like seeing that. This is our second email from Dr. Offit, who was a pediatrician

1:35.4

and the wife of Paul Offit, of course. She wrote, Hi Vincent and crew, I would really love to

1:41.2

hear you guys toss you guys toss around this newly published commentary. Seem spot on to me as we

1:48.0

continue to see waning, neutralizing antibodies in the setting of epidemiological evidence of

1:52.8

persistent protection against severe disease, after vaccination and or natural infection in the vast

1:58.5

majority. Perhaps the mRNA vaccine technology is even better at inducing strong T cell immunity

2:05.6

than we realize these authors certainly make a good case that measurement could serve as a better

2:10.5

correlate of immunity. The authors suggest that at the very least we need more research in this area

2:15.6

of T cell memory immunity. And she links to the paper we will talk about. Thank you. As always,

...

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