TWiV 1133: Gain of function makes us safer

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 21 July 2024

⏱️ 119 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Measles in Brooklyn NY (ABC) Measles in Washington DC (DC Health) Global childhood immunization stalls (WHO) Licensed H5N1 vaccines protect against circulating strains (Nat Med) Viruses moving without passports (European CDC) OC42-SARS-CoV-2 replacement spike virus (PNAS) Deep mutational scanning of Lassa virus glycoprotein (Immunity) Letters read on TWiV 1133 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Elemental sulfur found on Mars Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024 Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?) Alan – Nature sent an investigative reporter to a predatory conference Vincent – Coal-filled trains are likely sending people to the hospital Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This Week in Virology, the Podcast About Viruses, the kind that make you sick.
0:07.0	From Microbe TV, this is Twive, this week in Virology, episode 1133 recorded on July 19th,
0:20.4	2024.
0:22.4	I'm Vincent Rachin-Yello and you're listening to the
0:24.4	podcast all about viruses. Joining me today from Fort Lee, New Jersey, Dixon,
0:30.8	Despoier.
0:31.8	Hello Vincent and everybody else.
0:35.0	It's an amazing day on today.
0:37.0	It should be hotter than you know what, but it's not.
0:41.0	The humidity should be higher than you know what but it's not. We have my wife and I will have dinner out on our porch tonight
0:49.9	Whatever we have we will enjoy because we haven't been able to go outside for about a week and a half.
0:55.9	It's remarkable that's all here in New Jersey. It's 29c sunny and 41% humidity.
1:02.5	That's like half of what it's normally.
1:05.2	Also joining us from Austin, Texas, Ridge Condit.
1:09.2	Hi everybody.
1:10.8	I have to say that it's really good to see everybody. You guys are my friends and I really enjoy this. This is good fun. You know, I got warmed up because we had like 10 minutes of talking to each other in the pre-show that these
1:24.2	guys all miss. But this is great. Okay, so it's 90 degrees and partly cloudy and I have to say that for Austin in July that's like
1:38.1	Weird even okay it's not hot. It's not a hundred it's not a hundred and ten. I think last year at this time, last year was awful. We had you know many many days
1:49.3	Well over a hundred degrees And get this, next week starting Tuesday for the ensuing six days.
1:59.2	The forecast is for less than 90 degrees, as low as 84, okay, with significant possibility of rain.
2:08.4	This is great, except that I'm going to be in Maine where the forecast is even hotter than what it's going to be in Austin.
2:15.7	So there you go.
	...

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