TWiV 1132: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 20 July 2024

⏱️ 41 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode President Biden has COVID (CNN, USA Today) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn) Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM) Pemgarda infusion center locator (Pemgarda) Unable to access pemgarda, gotta call Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Combined treatment of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis) Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy) Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy (Lancet) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Isolation guidance (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID is defined (National Academies) Long COVID: the ANSWERS! (longcovidtheanswers.com) The FACTS: post COVID-19=long COVID? (WHO) The BASICS of long COVID-19 (CDC) Postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras (NEJM) Long Covid risk has dropped over time but remains substantial (CNN) Efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID (Clin Micro Inf) Diet and the gut microbiome: implications for health and disease (Nat Rev Micro) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1132 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This Week in Virology, the podcast about viruses, the kind that make you sick.
0:07.0	From Microbe TV, this is Twive this week in Vyrology.
0:16.0	Episode 1132, recorded on July 18, 2024.
0:22.0	I'm Vincid Rachin-yellow and you're listening to the podcast all about viruses.
0:27.0	Joining me today from New York, Daniel Griffin.
0:31.0	Hello everyone.
0:32.0	I think I've recognized that bow tie. I've seen it before Daniel, but I can't remember what it is.
0:38.0	It is apparently Plague, Orsinia Pestus, which apparently got a little debut in the news not too far back, but yeah, so some
0:50.0	interesting science about plague. I think we talked about it on Puskas about maybe
0:54.7	it's been with Western Europe for much longer than people had thought before. So some
0:59.6	interesting science there, but let's get into it today because we have a we have a bunch of things
1:04.4	happening so start with our quotation and this is back to Winston Churchill
1:09.9	who I quoted quite often during the dark days.
1:13.5	Courage is what it takes to stand up and speak.
1:17.2	Courage is also what it takes to sit down and listen.
1:21.1	Just sort of like that.
1:22.1	I was tossing over a couple of different quotations for this week, but it's been a difficult
1:28.4	week for a number of individuals, a number of prominent individuals, among them. We heard that of positive for SARS-Covi. He has COVID, but you know. And we heard that the
1:49.6	President promptly started. What did he start? Tax Loved. Yes. And there was an article in
1:57.7	USA Today and it was titled, Biden's Age makes COVID risky is his health in danger.
2:06.0	And there are a few quotations from apparently this Dr Daniel Griffin fellow.
2:13.2	And so I'll go through them.
	...

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