TWiV 1034: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 12 August 2023

⏱️ 37 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population, persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation, core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a influenza A vaccine candidate (The Lancet) Association between nose picking and SARS-CoV-2 incidence (PLOSONE) Effect of COVID-19 vaccination and booster on maternal-fetal outcomes (Lancet Digital Health) Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status (The Lancet) Does monoclonal antibody treatment for COVID-19 impact short and long-term outcomes (BMJ) Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and inflammation (Angiogenesis) Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts (STM) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1034 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.7	From microob TV, this is Twiv, this week in virology, episode 1034 recorded on August 10th,
0:20.4	2023. I'm Vincent Racken Yellow and you're listening to the podcast, all about viruses.
0:27.9	Joining me today from New York, Daniel Griffin. Hello, everyone. Does the COVID case numbers
0:36.2	continue to rise, Daniel? I have to say the COVID case numbers are getting high enough now,
0:42.3	and actually the hospital admissions high enough where actually we're having a discussion.
0:45.7	Do we need to have a COVID ward? I'm just because so many folks are getting admitted. So,
0:51.2	yeah, the numbers are still increasing and this is happening in several areas of the country.
0:56.2	We have our theories, just standard infection things, right? Transmission people are inside,
1:03.0	they're gathered, and this is a respiratory pathogen. So, yeah, we are seeing.
1:08.1	I think the answer is, Daniel, that August is the new December.
1:14.2	Is that what it is? Okay. And I see you wearing orange because orange is the new black.
1:19.0	Okay. Let me jump right in with our quotation. Gatsby believed in the green light, the
1:27.3	orgastic future that year by year recedes before us. It eluded us then, but that's no matter.
1:33.5	Tomorrow, we run faster, stretch out our arms farther, and then one fine morning.
1:39.6	So, we beat on boats against the current, worn back ceaselessly into the past.
1:45.5	And a couple of reasons why that F Scott Fitzgerald quotation from the end of the great
1:50.5	Gatsby will be relevant today. Maybe one of them was the one you just brought up. You know,
1:55.6	so many people thought we were through this, and now I'm getting a lot of people saying,
1:59.5	you know, I sort of wished I could forget about COVID, but now I feel like I need to be up to date
2:04.4	on what's going on. So, we're still here. And after a couple of mentions of RSV and influenza,
2:10.0	we'll get right into COVID. But first, I think this is on a lot of people's mind and a lot of
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