TWiV 1028: Asymptomatic SARS-CoV-2 infection and T cells

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 23 July 2023

⏱️ 115 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server First gene therapy for hemophilia A approved (FDA) Luxurna, gene therapy for vision loss (FDA) Anti-RSV monoclonal antibody approved (FDA) Trial of single-dose Nirsevimab (NEJM) Letters read on TWiV 1028 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Phoenix hits 110 degrees for the 19th day in a row, setting national record Brianne – James Webb Telescope One Year Anniversary Photo Kathy – Drone awards photos Alan – WHO Film Festival winners Vincent – Thinking, Fast and Slow by Daniel Kahneman Listener Picks David – The Mass Extinction Debates: A Science Communication Odyssey Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Transcript

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0:00.0	This week in Virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is TWIV, this week in Virology.
0:15.7	Episode 1028 recorded on July 21st, 2023. I'm Vincent Draghaniello and you're listening to
0:24.9	the podcast all about viruses. Joining me today from Fort Leigh, New Jersey, Dixon Depomye.
0:33.3	Hello, Vincent and everybody else. Looking at my window, I have a very nice window view of the
0:39.1	George Washington Bridge. I didn't mention that before, but I do well now. It's got nice puffy
0:44.9	clouds and it looks like a nice day, but it's still hot in humans. So I think it's probably up
0:51.3	around 85 degrees in humidity about 65 percent. That's how it feels. I don't know what the numbers
0:57.4	are, but that's how it feels. Here it is 28C and raining. It's raining where you are? It is.
1:06.1	You're in Midtown in New York. I can see you from here. I'm a few miles from you. It's not
1:12.2	raining. It's enough to do it. Also joining us from Western Massachusetts, Alan Dove.
1:17.3	Good to be here. Yeah, storms are extremely local sometimes. We have
1:22.5	currently at this very moment, I think it's not raining, but it could be again any moment. It's been
1:28.7	in and out. They've got a severe thunderstorm watch. 79 Fahrenheit, 26C, and it's about 69 percent
1:36.8	humidity. So it's just kind of a rainy summer day. Let's also joining us from Ann Arbor
1:44.8	Michigan, Kathy Spindler. Hi, everybody. Here it's 78 Fahrenheit, which is 26 Celsius.
1:51.6	We have nice white puffy clouds. It's just incredibly pleasant. 50 percent humidity, 21 mile
1:58.2	visibility. Yesterday, however, we had typical Ann Arbor art fair weather where there was a
2:04.3	severe thunderstorm. In fact, they in advance closed art fair from three to five PM and then by
2:11.9	five thirty, this sidewalks were all dry and art fair resumed. So there you go. How long did it
2:18.8	go? Oh, it goes till seven or eight or nine. I'm not sure each night Thursday, Friday, Saturday.
2:26.5	Cool. Also joining us from Madison, New Jersey, Brienne Barker. Hi, it's great to be here. It is
	...

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