Trihexyphenidyl (Artane) Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 10 March 2022

⏱️ 9 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this episode, I breakdown trihexyphenidyl (Artane) pharmacology, adverse effects, and drug interactions.

Trihexyphenidyl is highly anticholinergic and can cause constipation, dry eyes, dry mouth, and urinary retention.

Dementia medications like donepezil can have their effects blunted by the use of trihexyphenidyl.

Trihexyphenidyl is an older anticholinergic that is rarely used for the management of EPS caused by antipsychotics.

Transcript

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0:00.0	Hey all, welcome back to the real-life pharmacology podcast.
0:03.7	I'm your host pharmacist, Eric Christensen.
0:05.5	Thank you so much for being with me today.
0:08.3	I'm going to talk about trihexifenidil today, but first I want to remind you about our free top 200 study guide.
0:19.5	It's a 31-page PDF, great resource for anyone in nursing school,
0:24.4	pharmacy school, med school, anybody studying pharmacology. I put in there things that you actually
0:30.5	see in practice as well as a lot of things that show up on board exams. So definitely go check that out.
0:38.1	It's 31 pages absolutely for free.
0:40.8	Simply an email.
0:41.9	We'll get you access to that.
0:43.3	And of course, we'll get you updates when we've got new podcasts and content out as well.
0:48.3	So again, real-life pharmacology.com.
0:50.8	Subscribe to get that top 200 study guide.
0:54.8	All right. So drug of the day is trihexyphenidil.
0:59.1	Brand name of this medication is artane.
1:02.3	It has been quite a while since I have seen this medication utilized, but I do see it on
1:08.8	occasion.
1:10.5	This is technically classified as an anticholinergic medication.
1:16.0	Also can be classified as an anti-Parkinson's agent.
1:20.4	I will say the use for it being a Parkinson's type agent is very limited.
1:27.9	That's due to usually elderly people have Parkinson's type agent is very limited. That's due to usually elderly people, have Parkinson's, more so than younger people,
1:32.9	and having anticholinergic effects in elderly people.
	...

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