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Forbes Daily Briefing

This Startup Wants To Use Mini Robots To Treat Alzheimer's

Forbes Daily Briefing

Forbes

Business, Tech News, News

4.418 Ratings

🗓️ 16 April 2026

⏱️ 7 minutes

🧾️ Download transcript

Summary

For the past few months, neurosurgeons at hospitals in Florida, Connecticut and New York have been preparing for a wildly experimental operation designed to treat Alzheimer's disease, the dementia that leads to devastating memory loss. The surgery, which they've been practicing on cadavers, aims to clear the drainage pathways to the brain. This could help patients' own lymphatic systems flush out toxins that scientists believe are the hallmarks of the disease, which affects 7 million people in the U.S. alone.  To do so, they're turning to the smallest surgical robotic instruments in the world that can hold tiny needles the size of eyelashes, with scissors and dilators roughly the width of a human hair. The lymph vessels in the neck that surgeons would operate on for the Alzheimer’s procedure can be as little as 0.2 millimeters in diameter, the equivalent thickness of two sheets of paper. “It’s like taking a couple of strands of your hair and tying them together with little bitty sutures,” says Mark Toland, CEO of Jacksonville, Florida-based startup MMI, which makes the microrobots.  They aim to perform the first of these microrobotic surgeries on five people in March. While a very early-stage clinical study, it builds off reports from some 5,000 experimental surgeries performed in China and other Asian countries over the past five years that help the lymphatic system clear out build-up in the brain. They've shown remarkable, if largely anecdotal, results. Surgeons were not only able to slow the disease’s progression — they took patients with moderate Alzheimer’s back to a more mild stage of the disease, Toland says. By Amy Feldman, Senior Editor. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

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Your home won't feel booby trapped. It'll feel just like

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new British gas taking care of things and looking after you. T's and C supply excess options

0:28.9

available per repair. For the past few months, neurosurgeons at hospitals in Florida, Connecticut,

0:35.4

and New York have been preparing for a highly experimental

0:38.6

operation to treat Alzheimer's disease, a form of dementia that causes devastating memory loss

0:44.3

and affects about 7 million people in the U.S.

0:47.9

The surgery, practiced on cadavers, aims to clear the brain's drainage pathway so the body's

0:53.4

lymphatic system can flush out toxins believed to drive the disease.

0:58.0

To do so, surgeons are using microscopic robotic instruments developed by Jacksonville, Florida-based startup MMI.

1:06.0

These robots can hold needles the size of eyelashes with tools as thin as human hair.

1:12.3

The lymph vessels being operated on can measure just 0.2 millimeters in diameter.

1:17.7

MMI CEO Mark Tolan says, quote,

1:20.9

It's like taking a couple of strands of your hair and tying them together.

1:25.1

The team had scheduled plans to perform the first micro-robotic surgeries

1:28.5

in five patients in March. While still early stage, the trial builds on roughly 5,000

1:34.4

experimental surgeries conducted in China and other Asian countries over the past five years.

1:40.4

Those procedures, though largely anecdotal, suggest surgeons may be able to slow Alzheimer's progression

1:46.8

and, in some cases, move patients from moderate back to milder stages of the disease.

1:53.9

In November, MMI received approval from the Food and Drug Administration to begin trials, starting

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