Hi everybody I'm Diane Brady. I'm here at the Founders Forum with Dr. James Pire

who is the founder and CEO of Cambrian Bio. Nice to see you.

Hey Diane, nice to see you too.

I want to go back to the very beginning because you had a venture fund that was involved in sort

of helping scientists to basically commercialize what they were doing.

So take us back to what did you want to be when you grow up

because you have this fascinating company now.

Well, so it started for me, I guess, a bit of a somber note.

When I was a teenager, my grandfather died of cancer.

And as I was watching him get sick and ultimately die, I decided, or I observed that the treatments that he could get had really no chance of saving

his life, maybe just

in agony, right, in agony, right, in a place of suffering.

And at around that time, this was now close to 20, 25 years ago,

we were just starting to make scientific breakthroughs in animals, right?

Worms and flies, not even really mice yet, where you could change one gene.

This is after we'd mapped sort of the...

It was right as that was happening, right?

Right as we were sequencing the genome,

we were getting all of these new tools to do molecular biology for the first time in living organisms.

And we could change one gene and double the lifespan, healthy lifespan of an animal.

And I was like, that's the future not just waiting for

someone to get sick and then trying to deal with a complex disease like cancer

...