The Y chromosome has finally been sequenced: here’s why it matters
Science Weekly
The Guardian
4.2 • 1K Ratings
🗓️ 24 August 2023
⏱️ 18 minutes
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| 0:00.0 | This is the Guardian. For decades, scientists have been attempting to read the human genome, what makes each of us us in its entirety. |
| 0:22.0 | But there's been one mysterious piece that has stumped them until now. |
| 0:28.0 | The Y chromosome, one of the two sex chromosomes, has finally been fully sequenced. |
| 0:37.0 | So today we're diving deep into the fascinating story of the Y chromosome, to find out about its role in the body, |
| 0:45.0 | what we know about how it influences everything from male development, health and |
| 0:49.6 | fertility all the way to forensics, and why some scientists think one day it could disappear |
| 0:56.3 | altogether. From the Guardian I'm Madeline Finley and this is Science Weekly. |
| 1:09.0 | Mark Jubling, your professor of genetics at the University of Leicester and so tell me what you |
| 1:15.1 | make of these new studies finally fully sequencing the Y chromosome. How much of a |
| 1:21.1 | step forward is this? Well I think what they've done is something that people thought for a long time was impossible, |
| 1:26.0 | which is to determine the DNA sequence of this very difficult little chromosome. So the wide chromosome is small but it's full of |
| 1:36.0 | very weird and difficult knotty bits of DNA that have really resisted sequencing for a long time. So both of these studies have used |
| 1:45.4 | really new technologies to tackle that problem and although it's a great |
| 1:50.8 | achievement they don't actually tell us a huge amount that's totally new. |
| 1:55.2 | We had the picture before it was just kind of out of focus. |
| 1:58.8 | So if you like what these have done is it's a bit like turning on high definition TV and that you can suddenly |
| 2:04.3 | see absolutely everything in its gory details. Now before we get into why that has |
| 2:10.8 | been so difficult and more about the Y chromosome itself. |
| 2:14.3 | Perhaps you can go over some basics for me. |
| 2:17.0 | What are chromosomes exactly? What do they do? |
| 2:20.5 | Chromosomes are bits of DNA. So our DNA is what determines many of our features and |
| 2:28.6 | determines the proteins that are made in cells and so forth and it's information. |
... |
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