4.6 • 1.7K Ratings
🗓️ 23 October 2025
⏱️ 14 minutes
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In this episode, I’m uncovering some little-known, powerhouse supplements that could truly elevate your health. Ready to learn about supplements that go beyond the basics? Don't miss out and listen to the full episode!
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| 0:00.0 | Welcome to the Dr. Gundry podcast, where Dr. Stephen Gundry shares his groundbreaking research from over 25 years of treating patients with diet and lifestyle changes alone. |
| 0:11.1 | Dr. Gundry and other wellness experts offer inspiring stories, the latest scientific advancements, and practical tips to empower you to take control of your health and live a long, happy life. |
| 0:24.0 | As many of my longtime listeners will know, I'm always on the top of latest research regarding |
| 0:29.7 | exciting compounds that support your health. And as soon as the research is available, |
| 0:34.8 | I like to bring it to you right here. I also like to try it out on myself and |
| 0:39.2 | my patients. So today I want to talk about some of the best supplements that are available right |
| 0:44.1 | now, but not very many people have heard about. So number one is spermidine. Now I'll give you |
| 0:51.4 | one guess where that compound was first discovered, and it's a naturally |
| 0:57.2 | occurring compound in the body. But it plays a crucial role in cellular function and survival. |
| 1:04.3 | In fact, spermidine is one of several polyamines, including putresene, |
| 1:13.3 | these actually regulate cellular function. |
| 1:16.9 | Now, how does it work? |
| 1:17.9 | Well, spermidine is very critical for the process of autophagy. |
| 1:23.2 | Now, you may remember the word atophagy. |
| 1:25.9 | I've talked about it a lot. |
| 1:27.2 | I've written about it in my books. |
| 1:29.0 | Normally, cells die. And when cells die, one of two things can happen. One is that the cell |
| 1:39.6 | literally explodes. And it's called apoptosis. Apoposis is really bad for you for multiple |
| 1:47.8 | reasons. I've written about this in multiple of my books. Among the other really bad things |
| 1:53.5 | about your cell exploding is the mitochondria in the cell also explode. And mitochondria, you mightacondria, you might recall, are actually containing bacterial DNA. |
| 2:07.3 | And your immune system views this mitochondrial DNA as bacteria and produces inflammation. |
| 2:16.5 | So cells dying by apoptosis is a bad thing. On the other hand, |
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