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The Dr. Leaf Show

The Science of Aging Well (What Most People Miss)

The Dr. Leaf Show

Dr. Caroline Leaf

Health & Fitness, Mental Health

4.7 • 3.3K Ratings

🗓️ 30 March 2026

⏱️ 40 minutes

🧾️ Download transcript

Summary

Longevity is having a moment. But a lot of the conversation skips past the basics and goes straight to the extreme—biohacks, expensive protocols, the next big thing. So what actually moves the needle when it comes to aging well? Dr. Caroline Leaf sits down with Dave Watumull, Co-Founder and CEO of AX3 Life, to talk about one of the most researched—and quietly underrated—compounds in the longevity space: astaxanthin. And while that's where the conversation starts, it goes a lot deeper than supplements. They get into the real difference between lifespan and healthspan, why your internal environment matters more than any product, and how chronic stress and unmanaged thought patterns can actually speed up biological aging. They also cover: What astaxanthin is, where it shows up in nature, and why researchers are paying attention How oxidative stress and "inflammaging" wear on the body over time What to actually look for—and push back on—when evaluating supplements What the latest longevity research tells us, and what it doesn't The throughline of the whole conversation? You can't out-supplement a stressed mind. If you want a clearer lens for thinking about long-term health—and where tools like this actually fit in—this one's worth your time. Resources: Learn more about AX3® Bio-Pure Astaxanthin: https://ax3.life Use code DRLEAF for 20% off your first order

Transcript

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0:00.0

Dave, I'm so excited to talk to you because longevity is on the top of everyone's mind.

0:10.3

And with this podcast, we talk about mind and how mind changes the brain and the body.

0:15.3

There's so much talk in our current day and age about health span versus just increased lifespan.

0:23.9

You've spent over 25 years focused on one molecule. So what is the molecule and what made it worth that kind of level of commitment?

0:29.1

It's a pleasure to speak with you about this amazing molecule called astazanthin, which is actually,

0:34.0

it's a naturally occurring marine molecule that's present in microalge and salmon and

0:39.5

shrimp. And it's actually what gets salmon their beautiful pink and red coloration. And it turns out,

0:44.9

though, that in addition to just being a pigment, it's a really powerful and really unique

0:49.9

antioxidant and anti-inflammatory that turns out is systemically distributed throughout the whole body.

0:56.1

Microalgae are green when they start off life. And then when the sunlight hits them and stresses them,

1:02.0

they produce asazanthin as a defense mechanism to shield them against the UV light and the damaging

1:08.2

effects of the sun. And then from there, it works its way up the food chain. And so the scientists had this really great technology to grow this

1:15.6

microalgae. And at the time, there was only maybe less than 200 peer-reviewed papers. There were no

1:21.1

human clinical studies. But there were some intriguing hints in the research demonstrating that

1:26.0

it's a powerful antioxidant,

1:32.7

anti-inflammatory, and exceptionally safe. For the salmon, it's not just giving them their color,

1:37.8

but it's giving them strength and vitality. And without it, they probably wouldn't be able to swim upstream in that amazing strenuous journey to reproduce. Because ultimately, they're swimming

1:42.7

against the currents. They're not really consuming food. They're basically wasting away in this miraculous journey upstream. And the

1:49.2

asazanthan helps to protect their muscles against damage as they're swimming upstream. And then ultimately,

1:55.2

the salmon, when they lay their eggs, the asazantham is transferred to their eggs. And that's why

1:59.7

the eggs are red as well and protects

2:02.1

the eggs against the UV light in the shallow waters where the eggs are laid and then ultimately

...

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