The New Science of Neuroinflammation and How to Protect Your Brain with Dr. Austin Perlmutter

Dhru Purohit Show

Dhru Purohit

Alternative Health, Medicine, Health & Fitness

4.7 • 3.6K Ratings

🗓️ 15 September 2022

⏱️ 107 minutes

🔗️ Recording | iTunes | RSS

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Summary

This episode is brought to you by ButcherBox and Cozy Earth. Over 300 million people around the world experience depression. For the last half-century, the dominant explanation for depression has centered on serotonin. The basic idea is that low levels of brain serotonin or serotonin activity lead to symptoms of depression. But in the last several decades, a number of researchers have challenged the idea that serotonin plays a principal role, or even a major role, in depression. So, if it’s not a serotonin issue, what is it? Today on The Dhru Purohit Podcast, Dhru and Dr. Austin Perlmutter talk about why serotonin may not explain depression, but research on other brain pathways may provide answers such as neuroplasticity, our hormones, metabolic health, gut health, and the immune connection to the brain. They also discuss how there is a lot we can do through our lifestyle choices to help prevent and even manage depression. Dr. Perlmutter is a board-certified internal medicine physician and expert on how environmental influences affect our mental and brain health. He is a coauthor of the New York Times and international bestseller Brain Wash, which he wrote with his father Dr. David Perlmutter, and he hosts the Get The STUCK Out podcast. He currently serves as the Senior Director of Science and Clinical Innovation at Big Bold Health, where he is running an IRB-approved pilot trial exploring the effects of polyphenols on epigenetic expression. In this episode, we dive into: -The top drivers of depression (1:42) -The connection between neuroinflammation and depression (9:30) -How our immune system influences our brain function (11:49) -What governs our brain state and how we make decisions (16:04) -The top causes of inflammation (17:31) -How exposure to particulate matter impacts our brain function (36:21) -The top foods for brain health (44:15) -Why depression is not a serotonin issue (50:37) -Myths about serotonin (56:47) -What you can do to improve your brain health (1:16:22) Also mentioned in this episode: -Dr. Mark Hyman’s Himalayan Tartary Buckwheat Pancake Recipe For more on Dr. Perlmutter, follow him on Instagram @draustinperlmutter, Facebook @draustinnperlmutter, and through his website austinperlmutter.com. This episode is brought to you by ButcherBox and Cozy Earth. ButcherBox has a variety of different boxes, and you can choose your box and frequency. For a limited time, you can sign up today and get 2lbs of ground beef free for a whole year by going to butcherbox.com/dhru. Cozy Earth are the most comfortable, temperature regulating, and nontoxic sheets on the market. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code DHRU. Hosted on Acast. See acast.com/privacy for more information. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	300 million plus people around the world right now experiencing depression.
0:04.3	The most important thing is there's a lot that we can do through our lifestyle choices
0:08.4	to help positively improve our mood, potentially help prevent and even manage depression.
0:13.9	Welcome to the Drew Proid podcast. Each week we explore the inner workings of the brain and the
0:18.7	body with one of the brightest minds in wellness, medicine and mindset. This week's guest is Dr. Austin
0:24.8	Perrometer and today we're talking all things neuroinflammation. What are the top drivers,
0:31.5	especially lifestyle drivers that cause inflammation not only in the body but especially inside the
0:39.6	brain and also what are the top things that we can do to get to the root of neuroinflammation?
0:45.7	Starting with things of course diet but a few other categories that Dr. Perrometer
0:51.2	prioritizes for the patients that he sees. A little bit about Dr. Perrometer, he's a board certified
0:56.8	internal medicine physician and internationally recognized expert on how environmental influences
1:03.2	affect our mental and brain health. His research on lifestyle factors in depression have been
1:09.0	featured in cited and peer reviewed literature and he educates on the topic on top podcast and keynote
1:14.9	presentations around the world. He's a co-author of the New York Times and International bestselling book
1:20.4	Brainwash which he wrote with his father Dr. David Perrometer and in the book he covers our poor
1:26.5	modern day brain health and the role of everything from diet to social media on our cognitive
1:32.7	and mental state. We expand on all these topics and much more in today's interview. I hope you
1:37.7	enjoy. Austin, welcome back to the podcast. It's pleasure to have you here. I want to jump right in
1:43.5	on our conversation today about depression and you know there was a big study that came out. We're
1:48.5	going to chat about it in a second talking about how really for the last more than a decade,
1:54.1	really multiple decades now, this idea that depression is a serotonin deficiency and it's all about
2:02.0	a chemical imbalance is really just to speak plainly kind of bullshit. So if it is bullshit,
	...

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