Hacking Oxytocin, How to Use Rapamycin, Level Up Your At-Home Cold Plunge, Curing Asperger’s & More! AMA #1 with Dave Asprey : 1255

The Human Upgrade with Dave Asprey

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.6 • 7.3K Ratings

🗓️ 27 February 2025

⏱️ 60 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life!

In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there!

What You’ll Learn:

• How to naturally boost oxytocin for better relationships and emotional health

• The fastest way to upgrade your cold plunge for heat shock benefits

• Is rapamycin really a longevity miracle? Dave’s personal take

• How mitochondria impact brain power, mood, and aging—and how to fix them today!

• The shocking reason some people can’t process reality correctly (and how to retrain your brain)

• The real truth about stem cells, exosomes, and V-cells for regeneration

• The hidden dangers of selenium, thyroid supplements, and over-fasting

Transcript

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0:00.0	There are groups of people working with autistic kids right now on advanced spiritual stuff.
0:05.8	Sometimes their brains can do things that you just wouldn't think any humans capable of.
0:10.0	When they study Einstein's brain, it wasn't bigger, it was more efficient.
0:13.4	So the more efficient brands are the higher performing brains.
0:15.8	A brain that has mitochondrial dysfunction, which is part of Asperger's or autism, it's going to be a low power brain.
0:22.3	Your job is to have better mitochondria because that makes you younger, it makes you smarter, it makes you happier, it makes you perform better, and it makes you kind and more loving and improves relationship.
0:31.3	Everything is better when your mitochondria better.
0:33.2	But how are you going to have control over anything if you don't even have awareness over it?
0:37.8	You're listening to The Human Upgrade with Dave Asprey.
0:44.1	Welcome to the Human Upgrade AMA. These are questions submitted by our premium group,
0:50.6	The Upgrade Collective. If you're watching this show right now and have a question for me
0:54.9	that you'd like me to answer in a future video, please click the link to the Upgrade Collective
0:59.8	page in the description and take a look at our membership. In the near future, we'll be adding
1:04.7	even more to this membership, including an approachable monthly plan, so keep an eye out and enjoy the show.
1:13.2	How do cold plunges and alpha lupoic acid impact health?
1:18.4	With alpha lipoic acid, there's about a four-hour window when it's really active.
1:23.7	I think the half-life is four hours.
1:25.6	So then if you really wanted to elevate your levels,
1:28.8	you would take it every four hours. And some people use it for chelating mercury, and they suggest
1:33.1	taking alpha lipoc acid every four hours, even waking up to do that. That seems a bit obsessive to
1:37.9	me. But if you're trying to heal your liver with alpha-lipode acid, you'd want to be able to do probably multiple times a day.
1:48.0	My guess is three, maybe four times a day would be plenty to do it.
	...

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