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Valuetainment

“The Microbiome Is Your Second Brain” - Dr Rhonda Patrick WARNS How Gut Health Can Shorten Your Life

Valuetainment

Valuetainment Episodes

Business

4.81.7K Ratings

🗓️ 19 February 2026

⏱️ 9 minutes

🧾️ Download transcript

Summary

Patrick Bet-David and Rhonda Patrick dive into the gut microbiome and its impact on inflammation, brain health, anxiety, and aging. They break down LPS, leaky gut, probiotics, fermentable fiber, and how diet and exercise shape your mood, cognition, and long-term health.

Transcript

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0:00.0

Could AI help you do more of what you love?

0:03.1

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0:08.4

We help you handle the have-to-dos so you can focus on the can't-wait-to-dos.

0:13.2

It's a new workday.

0:15.1

Gut microbiome, okay?

0:18.6

What do we, what does the gut tie to? Is there stress? Is it aging? What does the gut tie to?

0:25.7

It ties to everything. I mean, so the gut is the first organ that sees the food that you take in, right? So it's really prone to inflammation because of that food is inflammatory,

0:40.1

even if you're eating a healthy diet. When you put food in your gut, it is forcing the gut to work.

0:46.5

And so you do cause some amount of inflammation in the gut no matter what. If you're eating

0:51.7

an unhealthy diet and you're overweight or obese, that

0:54.8

inflammation gets worse. And what I mean by inflammation is your gut epithelial cells open up and

1:00.2

they release something that's in the gut because you have trillions of bacteria in there, the gut

1:04.9

microbiome, as you mentioned. Well, the gut microbiome, those bacteria aren't always living.

1:09.5

Some of them are dying off constantly.

1:15.9

You're making new ones. You're dying off. Well, bacteria have something on their outer cell membrane called lipopolysaccharide, or LPS for short. And that gets released into blood system when you eat a meal.

1:22.7

And when that meal is really, really big, more of it gets released. When that meal is high

1:26.5

inflammatory, if it's refined sugar, saturated fat, more of it gets released. When that meal is high inflammatory, if it's refined sugar, saturated fat, more of that gets

1:29.5

released.

1:29.9

When that LPS gets into circulation, it activates your immune system and it causes inflammation.

1:35.9

That affects the brain.

1:36.9

There's studies showing that if you inject LPS into a normal, healthy person or a placebo-salin

1:42.2

control, they get inflammation in their brain, they get depressive

...

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