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MeSsy with Christina Applegate & Jamie Lynn Sigler

The Impact of Inflammation with Dr. Will Cole

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

Personal Journals, Health & Fitness, Society & Culture

4.9 • 3.7K Ratings

🗓️ 13 January 2026

⏱️ 63 minutes

🧾️ Download transcript

Summary

This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy #mudwtrpod Grow TherapyWhatever challenges you’re facing, Grow Therapy is here to help. Sessions average about $21 with insurance and some pay as little as $0, depending on their plan.  Visit https://GrowTherapy.com/MESSY today to get started.

Transcript

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0:00.0

Hi, I'm Christina Applegate. And I'm Jamie Lynn Sigler. And this is messy.

0:10.5

The following message is brought to you by Novartis. Hi, I'm Jamie Lynn Sigler. When it comes to relapsing MS treatments, your choice

0:22.7

matters. That's why talking to your doctor about your options is a big deal. But how do you know

0:27.2

what to ask? Figuring that out can be daunting. That's why I partner with Novartis to create an

0:32.9

MS treatment decision guide. It's packed with helpful info and questions for your doctor to help make an informed decision.

0:39.7

Trust me, the more prepared you are, the more confident you'll feel.

0:42.9

Download the guide right to your phone, only at Treatmentdecisionguide.com.

0:58.3

Hello, everybody. Welcome to Messy. This is Jamie. And Christina.

1:02.1

Yes. Why did I say it like that, Jamie? That was really weird.

1:15.0

That's who you are today. Christina. Christina. Christina. We have such a wonderful guest today, who I just told not only are Christina and I excited to talk to about everything for our own individual needs and purposes, but I think it's going to represent

1:20.3

all of you that are listening. Because today we have Dr. Will Cole, who's a functional

1:25.0

medicine expert, New York Times best-selling author of multiple

1:28.3

books. I've been a fan of his, I told him, I think I'm an OG fan, like from the beginning,

1:34.3

because he's just been ahead of the curve when it comes to gut health and inflammation and hormone

1:39.4

balance, been talking about this way before it's been trendy as of late. And he just helps us understand

1:46.3

the things that make or break how we feel every day and gives attainable tools and information

1:52.0

that can empower you to feel like you have the opportunity to live your best life. So please

1:56.5

welcome to messy Dr. Will Cole. Hi guys. Thanks for having me. I appreciate it.

2:02.6

We appreciate it so much. So thank you for being here.

2:07.0

Before we begin with our specific questions, do you mind just telling us in our audience a little bit about how you got into the work that you're in?

2:14.7

Yeah. So I grew up. My dad was a bodybuilder in the 80s and 90s. I thought

2:21.3

it was normal to have your dad, like, lubed up with baby oil and a turquoise speedo. But, like, so

...

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