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Life Kit

The dos and don'ts of taking over-the-counter pain medications

Life Kit

NPR

Education, Kids & Family, Self-improvement, Business, Health & Fitness

4.54.9K Ratings

🗓️ 18 May 2026

⏱️ 22 minutes

🧾️ Download transcript

Summary

Ibuprofen, acetaminophen and aspirin — there are many over-the-counter pain medications available, but are they all the same? And how much should you really take? In this episode, pharmacists and a doctor cover your drug options, including side effects, dosage and what to reach for the next time you have a headache or fever. This episode was originally published on March 31, 2025.

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Transcript

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0:00.0

You're listening to Life Kit from NPR.

0:07.4

Hey everybody, it's Mariel.

0:10.4

For a decade plus, when I would get my period, I would have terrible cramps the first day,

0:15.9

and I would just ride it out.

0:18.6

Like I'd be doubled over, unable to leave the house, really. I tried heating pads,

0:23.4

which do help, but for some reason, I didn't think I should take a painkiller. I don't know,

0:28.2

I guess I just thought it was safer to go natural. But then one day when I was maybe 25,

0:33.6

I popped an ibuprofen, and then a short time later, the pain was gone.

0:38.2

It would start to creep back up again a little later.

0:40.6

And then I took another.

0:42.0

And after that, I was over the hump.

0:43.9

My cramps were manageable at that point.

0:46.5

I kind of regretted waiting that long.

0:49.3

I went through so much unnecessary pain.

0:52.0

Pain is a part of the human experience. We get cramps and aches and migraines.

0:57.6

We burn our hands cooking or trip and sprain an ankle. And when you're right in the middle of one

1:02.8

of these moments and feeling that pain deep down in your bones, pain killers, especially the

1:08.4

over-the-counter kind that are easy to get, they feel like a miracle.

1:12.8

Now, they are not without risks.

1:14.5

If you take over-the-counter painkillers the wrong way or take too many of them, you can have serious complications or even die.

1:22.0

And they can mask your problems, too.

1:24.5

Pain is there for a reason.

...

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