The Co-Founders of Claude AI Tell Oprah About the Impact Artificial Intelligence Has on Your Life

The Oprah Podcast

Harpo

Society & Culture

4.2 • 1.5K Ratings

🗓️ 19 May 2026

⏱️ 69 minutes

🔗️ Recording | iTunes | RSS

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Summary

The siblings and co-founders of Claude AI, the CEO, Dario Amodei, and the President, Daniela Amodei, sit down with Oprah for an in-depth discussion on Artificial Intelligence and its profound impact on all of us. Anthropic is one of the largest tech companies leading AI development including their enormously popular chatbot assistant Claude. Dario and Daniela discuss the ethical responsibility and moral questions that come with creating advanced A.I., their new model Mythos and share their thoughts around government regulation. They talk about the potential risks and benefits of A.I. in everyday lives, the impact on jobs and how it will affect children. The Amodei siblings also explain their headline-making refusal of the Pentagon’s request to remove guardrails from Claude and the behind-the-scenes discussions that helped shape their decision. 00:00:00 - Welcome Daniela and Dario Amodei, founders of Anthropic 00:01:47 - Dario on human extinction 00:04:40 - What is the AI race 00:08:00 - Athropic’s safety concerns 00:09:26 - Why they are a public benefit corporation 00:11:20 - How the siblings formed Anthropic 00:13:00 - Can AI be created responsibly 00:14:12 - Benefits and the harms 00:18:52 - People falling in love with AI 00:20:30 - Claude and underage users 00:22:18 - How Claude does not incentivize users 00:28:33 - Anthropic’s refusal to remove guardrails 00:35:10 - Hard decisions they have had to make 00;38:35 - What regulation should look like 00:40:45 - Should people view AI negatively? 00:43:00 - The AI problem to solve 00:48:20 - Men use AI more than women 00:49:30 - What is Mythos 00:53:20 - Does this keep them up at night? 00:54:15 - What keeps ego in check 00:58:20 - Will they get this right? 00:59:15 - Are there others doing this responsibly? 01:03:25 - What is the meaning of a well-lived life? Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	I was talking to parents recently who lost their son to suicide through a chatbot.
0:06.0	And their parents don't even know they're speaking to them.
0:08.0	We don't allow users under the age of 18 to use quad.
0:12.0	How do you know they're not lying?
0:14.0	Will we even be thinking anymore? Will there be a need to think?
0:17.0	What do you think of people falling in love with it now?
0:19.0	I think that's a bad idea. Do you want to be addicted to these things or do you want them to help you live your life?
0:24.6	It goes back, I think, Dario, to what I read that you'd said before, that we can only diffuse this at the speed of trust.
0:32.6	Trust, yes.
0:33.6	And trust is currently in short supply.
0:36.6	Something is happening to humanity with this technology, bigger than anything that, you know,
0:43.3	maybe it has happened in hundreds of years. And so we need to find some way for everyone to
0:48.3	be an active participant in what is happening.
0:52.3	Hi everybody and welcome to the Oprah podcast.
0:56.9	I'm here with two people who are shaping our present world and our future one.
1:02.4	And I hear you all don't love that description all the time, but it's the truth.
1:06.1	I think most people would agree that that is pretty accurate.
1:09.7	Dario and Daniela Amadeade had the global artificial intelligence company.
1:14.6	They found it, Anthropic, which right now at the time of this conversation is reportedly valued
1:20.6	at $900 billion.
1:23.6	And over a million people a day are signing up for Claude.
1:26.6	These are the parents of Claude.
	...

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